Around 2002 I became increasingly aware of the need for a novel concept to analyze the massively growing set of genomics and proteomics data. In 2005 and 2006 we recognized that weak links have a wastly different meaning, if they are intra-modular or inter-modular structures. During these studies we were able to identify creative nodes, which are highly dynamic, inter-modular regulators of system plasticity and evolvability. In the last 10 years the LINK-Group developed several novel algorithms downloadable from this website to analyze network topology and dynamics. We defined novel, dynamic network centrality measures, and are able to identify key nodes of network signaling and cooperation. We use this knowledge to predict and influence the positition of complex systems in their state-space. We apply our methods to propose and rank novel drug targets, as well as to predict drug side effects or chances for drug repositioning.
Other honors and awards
Publications (July 2014)