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Péter Csermely

As an ordinary biochemist, I have started to recognize the strength of the network approach only in 2002. This was the time, when I became increasingly aware of the need for a novel concept to analyze the massively growing set of genomics and proteomics data, and I recognized the special role of my original subject, molecular chaperones in the organization of the whole cell. Chaperones are typical weak linkers providing a large number of promiscuous contacts to stabilize network structures both at the level of individual proteins and cellular networks. In 2005 and 2006 we recognized that weak links have a wastly different meaning, if they are intra-modular or inter-modular structures. During these studies we were able to identify a special set of network elements, called VIP-elements or creative elements. Currently I am working on the role of weak links in the interaction scenarios (dynamic equilibria, games) between network partners.

Personal

Education

  • Master of Science (honours degree) 1982 Eötvös Loránd Univ. Budapest (chemistry, pharmaceutical chemistry)
  • Ph.D. (summa cum laude) 1983 Eötvös Loránd Univ. Budapest (colloidal chemistry, cell biology)
  • Ph.D. (summa cum laude) 1988 Hungarian Academy of Sciences (biochemistry, immunochemistry)
  • Habilitation: 1994 Semmelweis University (medicine, biochemistry)
  • DSc.1994 Hungarian Academy of Sciences (cell biology, medicine)

Research and Professional Experience

  • 1983-1986 Postdoctoral Fellow, Hungarian Academy of Science
  • 1984-1985 Visiting Scientist, State Univ. of New York, Syracuse, NY, USA
  • 1986,1987 Visiting Scientist, Hannover Medical School, Hannover, Germany
  • 1986-1988 Lecturer, Semmelweis University, Sch. Med., Budapest, Hung.
  • 1989-1995 Assistant Professor, Semmelweis Univ. Sch. Med., Budapest, Hungary
  • 1989 Visiting Scientist, Uniformed Services University, Bethesda, MD, USA
  • 1989-1991 Research Fellow, Joslin Diabetes Center, Harvard University, Boston, MA, USA
  • 1993,1994 Invited Scholar, Diabetes Forschungsinstitut, Düsseldorf, Germany
  • 1993, 95, 97 Invited Scholar, Tokyo Metropolitan Institute of Science, Japan
  • 1995-1999 Associate Professor, Semmelweis Univ. Sch. Med., Budapest, Hungary
  • 1999- Professor of Biochemistry
  • 2000- Invited professor: Denis Diderot University
  • 2000- 2003 Chief Scientist, Biorex Ltd., Hungary
  • 2012 Residency at the Rockefeller Foundation Bellagio Center

Comissions and Boards

  • 1986-96 Member of the Board of the Hungarian Society of Cell Biology (87-88, Acting Secretary; 93-96, Secretary of the Society)
  • 1992-2001 Member of the Board of the Sümeg Membrane Symposia
  • 1993- Member of the Committee on Cell and Developmental Biology of the Hungarian Academy of Sciences
  • 1994-97, 2007-10 Board member of the Hungarian National Science Foundation
  • 1994-99 Chairman of the all-European COST network B5 on non-insulin dependent diabetes mellitus (NIDDM)
  • 1995-2001 Trustee of the Hungarian National Academy of Sciences
  • 1995- Hungarian Biochemical Society (secretary general 1995-2005, vice-president, 2005-)
  • 1996-2008 Trustee of the Pro Renovanda Cultura Hungariae Fund
  • 1996-2005 Member of the Committee on Clinical and Experimental Oncology of the Hungarian Council of Health Sciences
  • 1997-2002 Member of the Cell Biology Review Panel of the Hungarian Ministry of Education Science Fund , 2000-2002 chairman of the Panel
  • 1998-2000 Member of the Research Council of Gedeon Richter Pharmaceuticals Ltd. Budapest
  • 1999-2001 Founding Secretary/ Treasurer of Cell Stress Society International
  • 1999-2007 Editoral Board member of Biogerontology
  • 2000-2007 Executive Board member of the Hungarian National Student Resarch Council
  • 2000-2005 Chairman of the all-European COST network B17 on diabetes, obesity and aging
  • 2000- Member and the Editorial Board of the journal "Physician Education"
  • 2002-2008 Member of the Hungarian UNESCO Committee
  • 2004-2008 Elected participant of the sessions of the Hungarian Academy of Sciences
  • 2005-2007 President-elect, president and past-president of Cell Stress Society International
  • 2005- Member of the Committee on Biochemistry and Molecular Biology of the Hungarian Academy of Sciences
  • 2006 - chairman of the Hungarian National Talent Support Council
  • 2006 Member of EU Young Scientists High Level Expert Group
  • 2007-2008 Member of the Hungarian National Council of Education
  • 2008-2010 Member of the Wise Persons' Committee of the President of Hungary
  • 2010- Editor of PLoS ONE
  • 2011- Editor of Cell Stress and Chaperones
  • 2011- Editor of (Nature) Scientific Reports

Honors and Awards

  • 1976 Apáczai Commemorative Medal
  • Natl. Chemical Competition, 2nd place
  • 8th International Olympics of Chemistry, 2nd place
  • 1977-1980 1st-3rd Natl. Competition of Organic Chemistry, 2nd, 3rd places
  • 9th, 10th International Competition of Analytical Chemistry, 2nd, 3rd places
  • 1980-1982 National Scholarship of Higher Education
  • 1981 Outstanding student of the Eötvös Loránd University
  • 1983 Outstanding student of the Hungarian Higher Education
  • 1986 Tankó Award of the Hungarian Biochemical Society
  • 1988 Celebrity of the Week -- Hungarian TV, channel 1
  • 1989 Presidential Silver Medal of Outstanding Work
  • 1989-91 Fogarty International Research Fellowship Award
  • 1995 Howard Hughes International Research Scholar's Award
  • 1996 Niveau Prize of the journal Nature (Hung.)
  • 1996 Tivadar Huzella Award for the best basic science investigator of the Semmelweis University
  • 1997 Széchenyi Award of Outstanding Hungarian Professors
  • 1998 Best Science Educator of the Semmelweis University
  • 1998 First BioTul Young Scientist Award
  • 1999 niveau prize of the Hungarian Journal "Nature"
  • 2000 Agoston Trefort Award
  • 2001 Ashoka Fellow
  • 2001 nomination for the Person of the Year Award in Hungary
  • 2002 Peter Pazmany Award (Pro Cultura Hungariae Fund)
  • 2002 Anyos Jedlik Award (Hungarian Patent Office)
  • 2002 Markusovszky Award for the best 2001 paper of the Medical Weekly
  • 2003 EMBO Science Communication Award
  • 2004 Best science communicator of the year (science journalist prize of Hungary)
  • 2004 Descartes Prize of Science Communication (top prize of the European Union)
  • 2005 The Order of the Republic of Hungary, Knight’s Cross
  • 2005 Golden Owl Award of the National Student Research Council
  • 2006 Példakép Award for being a role model in Hungary
  • 2009 Master-teacher, an award for being an outstanding mentor of undergraduates
  • 2009 Pro Talento (a golden pin for outstanding talent support)
  • 2010 the talent support activity becomes a part of the national heritage of Hungary
  • 2010 Széchenyi Society award
  • 2011 Spirit of Budapest Award of the Cell Stress Society International
  • 2011 Prima Award of the Prima Primissima Foundation
  • 2011 Márai Award: the Hungarian translation of Weak Links has been selected as one of the best 250 non-fiction books in Hungary recommended to all Hungarian libraries

Past research support

Current research support

  • National Science Foundation (Hungary, OTKA F5534; T17720; T25206; T37357, K69105, K83314) Stability of cellular networks. 35000 EUR/Year, 1992-2015.
  • European Union (TÁMOP-4.2.2/B-10/1-2010-0013) Magister talent development program. 40000 EUR/year, 2011-2012.

Publications (May 2012)

  • Number of scientific publications: 220
  • Number of independent citations: 6091
  • List of independent citations. Download it in pdf! PDF format
  • Cumulative impact factor: 602
  • h-index: 41 (number of papers with at least 40 citations)
  • w-index: 11 (number of papers with at least 100 citations)
  • papers contributing to Hungary's h-index: 3 (papers with at least 212 citations)
  • citation classic: 1 (papers with at last 400 citations)
  • List of best cited publications Download it in pdf! PDF format
  • z-index: 15 (number of papers with at least 7.5 impact factors
  • List of papers with largest impact factors Download it in pdf! PDF format (or in .doc)
1981
  1. Csermely, P. (1981) Reconstitution of gamma-glutamyl transpeptidase to egg-lecithin liposomes. Awarded works of the 15th National Conference of Student Researchers. Ministry of Education. Institute of Scientific Information, Budapest. vol. 4., pp. 225-226
1982
  1. Csermely, P., Müllner, N., Báthori, Gy., Varga, V., Somogyi, J. (1982) Reconstitution of gamma-glutamyl transpeptidase to liposomes. Proc. Natl. Acad. Sci. Hung. Sect. Biol. 25, 79-92
  2. Csermely, P. (1982) Reconstitution of gamma-glutamyl transpeptidase to liposomes. Thesis of M.S. degree, Eötvös Loránd Univ., Dept. Colloid Chem. Budapest.
1983
  1. Csermely, P. (1983) Reconstitution of gamma-glutamyl transpeptidase to liposomes and application of the model system. Ph. D. thesis. Eötvös Loránd Univ., Budapest.
1985
  1. Varga, S., Csermely, P. and Martonosi, A. (1985) The binding of vanadium(V)oligoanions to the Ca-ATPase of sarcoplasmic reticulum. Eur. J. Biochem. 148, 119-126 IF: 3.5 Download it! PDF format
  2. Csermely, P., Varga, S. and Martonosi, A. (1985) Competition between decavanadate and fluorescein isothiocyanate on the Ca-ATPase of sarcoplasmic reticulum. Eur. J. Biochem. 150, 455-460 IF: 3.5 Download it! PDF format
  3. Csermely, P., Martonosi, A., Levy, G.C. and Ejchart, A.J. (1985) 51-V-NMR analysis of the binding of vanadium oligoanions to sarcoplasmic reticulum. Biochem. J. 230, 807-815 IF: 3.7 Download it! PDF format
1986
  1. Csermely, P. (1986) Interaction of oligovanadate anions with the Ca-ATPase of sarcoplasmic reticulum. Biochemistry (Hung.) 10, 71-74
  2. Martonosi, A., Taylor, K.A., Ho, M.H., Dux, L., Varga, S., Csermely, Müllner, N., Jóna, I., Pikula, S., Ting-Beall, H.P. and Papp, S. (1986) The structure of Ca-ATPase in sarccoplasmic reticulum. In: F. Carpenedo, P. Debetto, M. Floreani, S. Luciani eds. Calcium ion: Membrane Transport and cellular regulation. Padova-Venezia, Italy, pp. 67-73
1987
  1. Csermely, P., Katopis, C. H., Wallace, B. A. and Martonosi, A. (1987) The E1 -> E2 transition of Ca-transporting ATPase in sarcoplasmic reticulum occurs without major changes in secondary structure. A circular dichroism study. Biochem. J. 241, 663-669 IF: 3.8 Download it! PDF format
  2. Varga, S., Csermely, P., Müllner, N., Dux, L. and Martonosi, A. (1987) Effect of chemical modification on the crystallization of Ca-ATPase in sarcoplasmic reticulum Biochim. Biophys. Acta 896, 187-195 IF: 2.3
  3. Martonosi, A., Dux, L., Taylor, K.A., Ting-Beall, H.P., Varga, S., Csermely, P., Müllner, N., Papp, S. and Jóna, I. (1987) The structure of Ca-ATPase in sarcoplasmic reticulum. In: Fambourgh, D.M., Hille, B. eds. Proteins and Excitable Membranes. New York: Wiley pp. 257-286
  4. Csermely, P. and Somogyi, J. (1987) The possible pitfalls of the measurement of intracellular calcium concentration in T lymphocytes with the fluorescent indicator quin2. Immunobiology 174, 380-394 IF: 1.9
  5. Csermely, P. and Somogyi, J. (1987) Determination of the intracellular calcium concentration with the fluorescent dye, quin2. Hospital and Technics (Hung.) 25, 33-38
  6. Csermely, P., Gueth, S. and Somogyi, J. (1987) The tumor promoter tetradecanoyl-phorbol-acetate (TPA) elicits the redistribution of zinc in subcellular fractions of rabbit thymocytes as measured by X-ray fluorescence. Biochem. Biophys. Res. Commun. 144, 863-868 IF: 3.3 Download it! PDF format
  7. Martonosi, A., Dux, L., Taylor, K.A., Csermely, P., Müllner, N., Pikula, S., Papp, S., Varga, S., Jóna, I. and Keresztes, T. The Ca-pumps of skeletal muscle sarcoplasmic reticulum. (1987) Acta Physiol. (Hung.) 22, 263-276
  8. Csermely, P., Fodor, P. and Somogyi, J. (1987) The tumor promoter tetradecanoyl-phorbol-acetate (TPA) elicits the redistribution of heavy metals in subcellular fractions of rabbit thymocytes as measured by plasma emission spectroscopy. Carcinogenesis 8, 1663-1666 IF: 2.9 Download it! PDF format
1988
  1. Csermely, P. (1988) Interactions between the sinalling systems of T lymphocytes: The role of zinc ions. Ph. D. thesis. Hungarian Academy of Sciences, Budapest
  2. Csermely, P., Szamel, M., Resch, K. and Somogyi, J. (1988) Zinc can increase the activity of protein kinase C and contributes to its binding to plasma membranes in T lymphocytes. J. Biol. Chem. 263, 6487-6490 IF: 6.5. Download it! PDF format
  3. Szamel, M., Kövecses, M., Csermely, P., Szollár, L., Goppelt, M., Resch, K. and Somogyi, J. (1988) The decisive role of Na-K-ATPase in stimulation process of T lymphocytes. In: Skou, J.C.; Norby, and Maunsbach, A.B. eds. Proc. of the 5th conference on Na-K-ATPases. New York: Alan R. Liss, pp. 449-456
  4. Csermely, P., Szamel, M., Resch, K. and Somogyi, J. (1988) Zinc increases the affinity of phorbol ester receptor in T lymphocytes. Biochem. Biophys. Res. Commun. 154, 578-583 IF: 3.2
1989
  1. Csermely, P. and Somogyi, J. (1989) Tumor promoter 12-O-tetradecanoyl -phorbol-13-acetate (TPA) can reduce the Ca-transporting ability of Ca-ionophores in T lymphocytes. Involvement of intracellular heavy metal ions. J. Cell Physiol. 138, 593-602 IF: 3.4 Download it! PDF format
  2. Tóth, S., Csermely, P., Beregi, E., Szkladányi, A. and Szabó, L.D. Decreased cytosolic free calcium concentration of aged human lymphocytes in resting state. Comprehens. Gerontology 3, 16-22
  3. Csermely, P., Sándor, P., Radics, L. and Somogyi, J. (1989) Zinc forms complexes with higher kinetical stability than calcium, 5F-BAPTA as a good example. Biochem. Biophys. Res. Commun. 165, 838-844 IF: 3.2
  4. Csermely, P. and Somogyi, J. (1989) Zinc as a possible mediator of signal transduction in T lymphocytes. Acta Physiol. Hung. 74, 195-199 IF: 0.2
1990
  1. Tóth, S., Csermely, P., Szkladányi, A. and Régius O. (1990) Changes in intracellular free calcium concentration in resting lymphocytes at the borderline of life. In: Centenarians in Hungary. A sociomedical and demographic study. Interdiscipl. Top. Gerontol. Karger, Basel vol. 27, pp. 134-145
  2. Csermely, P., Bálint, E., Grimley, P.M. and Aszalos, A. (1990) Protein kinase C is involved in the early signals of interferon-alpha but not of interferon-gamma in U937 cells. J. Interferon Res. 10, 605-611 IF: 1.4
  3. Goldstein, B.J., Meyerovitch, J., Zhang, W-R., Backer, J.M., Csermely, P., Hashimoto, N. and Kahn, C.R. (1990) Hepatic protein-tyrosine phosphatases and their regulation in diabetes. Adv. Prot. Phosphatases 6, 1-17
  4. Siddle, K., Nayak, R. and Csermely, P. (1990) The 64K question in diabetes (editorial) Lancet 336, 597-598
1991
  1. Csermely, P. and Kahn, C.R. (1991) The 90 kDa heat shock protein (hsp-90) possesses an ATP-binding site and autophosphorylating activity. J. Biol. Chem. 266, 4943-4950 IF: 6.7 Download it! PDF format
1992
  1. Csermely P. and Somogyi J. (1992) Heat shock proteins. Biochemistry (Hung.) 16, 19-23
  2. Csermely P. and Somogyi J. (1992) Heat shock proteins in medicine. Orvosi Hetilap (Medical Weekly, Hung.) 133, 1347-1351
  3. Somogyi, J. and Csermely, P. (1992) Zink als möglicher Mediator bei der Signalübertragung in zellulaeren Prozessen. In: Bioelemente und Swangerschaft (ed.: H. Weidinger) Blackwell Wissenschaft, Berlin. pp. 62-69
  4. DeMouzon, S.H., Csermely, P., Zoppini, G. and Kahn, C.R. (1992) Dissociation between c-myc and c-fos gene expression, DNA synthesis by epidermal growth factor receptor tyrosine kinase activity. J. Cell Physiol. 150, 180-187 IF: 3.0 Download it! PDF format
  5. Chatterjee, S., Goldstein, B.J., Csermely, P. and Shoelson, S.E. Design and synthesis of potent substrates and inhibitors of PTPases. In: Peptides: chemistry and biology (eds.: J.E. Rivier and J.A. Smith) ESCOM Science Publishers, Leiden, Netherlands, pp. 553-555
  6. Csermely, P. and Kahn, C.R. (1992) Insulin induces the phosphorylation of DNA-binding nuclear proteins including lamins in 3T3-F442A cells. Biochemistry 31, 9940-9946 IF: 5.2
  7. Meyerovitch, J., Backer, J.M., Csermely, P., Shoelson, S.E. and Kahn, C.R. (1992) Insulin differentially regulates protein phosphotyrosine phosphatase activity in rat hepatoma cells. Biochemistry 31, 10338-10344 IF: 5.2
  8. Csermely, P. (1992) Nuclear signalling, D.Sc. thesis. Hungarian Academy of Sciences, Budapest, Hungary
1993
  1. Csermely, P., Kajtár, J., Hollósi, M., Jalsovszky, G., Holly, S., Kahn. C.R., Gergely, P. Jr., Sőti, Cs., Mihály, K. and Somogyi, J. (1993) ATP induces a conformational change of the 90 kDa heat shock protein (hsp-90). J. Biol. Chem. 268, 1901-1907 IF: 6.8 Download it! PDF format
  2. Kahn, C.R., White, M.F., Shoelson, S.E., Backer, J.M., Araki, E., Cheatham, B., Siddle, K., Sun, X., Wilden, P.A., Yamada, K., Csermely, P., Folli, F., Goldstein, B.J., Huertas, P., Rothenberg, P.L. and Saad, M.J.A. (1993) The insulin receptor and its substrate: molecular determinants of early events in insulin action. Recent Prog. in Horm. Res. 48, 291-339 IF: 5.9
  3. Csermely, P., Schnaider, T., Cheatham, B., Olson, M.O.J. and Kahn, C. R. (1993) Insulin induces the phosphorylation of nucleolin: a possible mechanism of insulin-induced RNA-efflux from nuclei. J. Biol. Chem. 268, 9747-9752 IF: 6.8 Download it! PDF format
  4. Csermely, P., Tóth, S., Beregi, E. and Boross, M. (1993) Stress-induced changes of cytoplasmic free calcium in lectin-stimulated mouse T lymphocytes. Recent Advances in Aging Science, (eds.: E. Beregi, I.A. Gergely and K. Rajczi) Monduzzi Editore, pp. 121-124
1994
  1. Farkas, Gy., Buday, L., Csermely, P. and Faragó, A. (1994) Lipocortin I is not accessible for protein kinase C bound to the cytoplasmic surface of the plasma membrane in streptolysin-O-permeabilized pig granulocytes. Biochim. Biophys. Acta 1220, 315-322 IF: 2.5
  2. Csermely, P., Radics, L., Rossi, C., Szamel, M., Mihály, K. and Somogyi, J. (1994) The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes. Biochim. Biophys. Acta 1221, 125-132 IF: 2.5
  3. Saad, M.J.A., Folli, F., Araki, E., Hashimoto, N., Csermely, P. and Kahn, C.R. (1994) Regulation of insulin receptor, IRS-1 and phosphatidylinositol-3-kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin and dexamethasone. Mol. Endocrynol. 8, 545-557 IF: 7.8
  4. Somogyi, J., Vér, Á., Szántó, I., Kalff, K., Csermely, P., Kalapos, M., Bányász, T. and Kovács, T. (1994) Alterations in Na+/K+ATPase isoforms of different tissues in streptozotocin induced diabetes mellitus. In: The Sodium pump. Structure, mechanism, hormonal control and its role in disease (eds.: E. Bamberg and W. Schoner) Steinkopff Verlag, Darmstadt, pp. 876-879
  5. Csermely, P., Kajtár, J., Hollósi, M., Oikarinen, J. and Somogyi, J. (1994) The 90 kDa heat shock protein (hsp90) induces the condensation of the chromatin structure. Biochem. Biophys. Res. Commun. 202, 1657-1663 IF: 3.4 Download it! PDF format
  6. Csermely, P., Gergely, P., Nardai, G., Schnaider, T., , Sőti, Cs., Szántó, I. and Somogyi, J. (1994) Biochemistry of molecular chaperones. Biochemistry (Hung.), 18, 126-132
1995
  1. Csermely, P., Miyata, Y., Schnaider, T. and Yahara, I. (1995) Autophosphorylation of grp94 (endoplasmin). J. Biol. Chem. 270, 6381-6388 IF: 7.4 Download it! PDF format
  2. Vántus, T., Csermely, P., Mezo, I., Teplán, I. and Kéri, Gy. (1995) The somatostatin analog, TT2-32 induces a biphasic activation of phosphotyrosine phosphatase activity in human colon tumor cell line, SW620. Tumor Biology, 16, 261-267 IF: 1.1
  3. Csermely, P. (1995) Everyday stress in our cells. World of Nature (Hung.), 126, 318-320
  4. Csermely, P. and Tóth, S. (1995) Changes in intracellular calcium metabolism in T lymphocytes after transient and persistent psychosocial stress of mice of various ages. Age Vault. An INIA Collaborating Network Anthology (Ed.: S. Formosa), International Institute on Ageing, United Nations-Malta, 245-250
  5. Kellermayer, M.S.Z. and Csermely, P. (1995) ATP induces dissociation of the 90 kDa heat shock protein (hsp90) from F-actin: interference with the binding of heavy meromyosin. Biochem. Biophys. Res. Commun., 211, 166-174 IF: 3.2Download it! PDF format
  6. Vér, Á., Csermely, P., Bányász, T., Kovács, T. and Somogyi, J. (1995) Alterations in the properties and isoform ratio of brain Na+/K+ATPase in streptozotocin diabetic rats. Biochim. Biophys. Acta 1237, 143-150 IF: 2.5 Download it! PDF format
  7. Csermely, P. (1995) Traps of cognition. How objective can we remain during observation? World of Nature (Hung) 126, 434-436
  8. Csermely, P., Pénzes, I. and Tóth, S. (1995) Chronic overcrowding decreases cytoplasmic free calcium levels in the T lymphocytes of aged CBA/CA mice. Experientia, 51, 976-979 IF: 1.6
  9. Csermely, P. and Gergely, P. (1995) Traps of cognition. Hungarian Society of Cell Biology, book, pp. 141
  10. Csermely, P. (1996) Signalling in the cell nucleus. World of Nature (Hung) 127, 6-9
  11. Csermely, P., Schnaider, T. and Szántó, I. (1995) Signalling and transport through the nuclear membrane. Biochim. Biophys. Acta, 1241, 425-452 IF: 2.5 Download it! PDF format
  12. Somogyi, J., Vér, Á, Trója, G., Végh, E., Bühler, C., Hatfaludi, F., Csermely, P. and Popovic, S. (1995) Interference of the sulphonylurea antidiabeticum gliquidone with mitochondrial bioenergetics under in vitro conditions. Acta Physiol. Hung., 83, 299-312
  13. Somogyi, J., Vér, Á., Trója, G., Végh, E., Bányász, T., Csermely, P., Popovic, S. and Kovács, T. (1995) Interference of sulphonylurea antidiabetica with mitochondrial bioenergetics under in vivo conditions. Acta Physiol. Hung., 83, 313-321
  14. Vér, Á., Szántó, I., Csermely, P., Kalff, K., Végh, E., Bányász, T., Marcsek, Z. and Somogyi, J. (1995) Effect of streptozotocin-induced diabetes on kidney Na/K-ATPase activity. Acta Physiol. Hung., 83, 323-332
  15. Szántó, I., Gergely, P., Marcsek, Z., Bányász, T., Somogyi, J. and Csermely, P. (1995) Changes of the 78 kDa glucose-regulated protein (grp78) in livers of diabetic rats. Acta Physiol. Hung., 83, 333-342
1996
  1. Nardai, G., Schnaider, T., Sőti, Cs., Ryan, M.T., Hoj, P.B., Somogyi, J. and Csermely, P. (1996) Characterization of the 90 kDa heat shock protein-(hsp90)-associated ATP/GTP-ase. J. Biosciences, 21, 171-190 IF: 0.4 Download it! PDF format
  2. Csermely, P., Sőti, Cs., Schnaider, T., Steták, A. and Somogyi, J. (1996) The nuclear receptor superfamily. J. Medical Education. 71, 176-181
  3. von Holtey, M., Csermely, P., Niggemann, J. and Eckel, J. (1996) Insulin-induced phosphorylation of a 38 kDa DNA-binding protein in ventricular cardiomyocytes: possible implication of nuclear protein phosphatase activity. Molecular and Cellular Endocrinology 120, 107-114 IF: 2.6
  4. Csermely, P. (1996) When a scientist may become a writer. Hungarian Science 103, 205-206
  5. Csermely, P. (1996) When it is good to be a bad catalyst. Molecular chaperones as possible survivors of prebiotic evolution. Retort and Reactor (Hung.), 96/4, 3-8
1997
  1. Csermely, P. (1997) The beginnings of life. Current hypotheses of prebiotic evolution leading to life on Earth. World of Nature (Hung). 128, 10-14
  2. Csermely, P. (1997) Proteins, RNA-s and chaperones in enzyme evolution: a folding perspective. Trends in Biochem. Sci. 22, 147-149 IF: 18.8 Download it! PDF format
  3. Csermely, P., Miyata, Y., Sőti, Cs. and Yahara, I. (1997) Binding affinity of proteins to hsp90 correlates with both hydrophobicity and positive charges. A surface plasmon resonance study. Life Sci., 61, 411-418 IF: 2.3 Download it! PDF format
  4. Vér, Á., Szántó, I., Bányász, T., Csermely, P., Végh, E. and Somogyi, J. (1997) Changes of Na+/K+-ATPase mRNA and protein levels in diabetic rat heart left ventricle. Diabetologia 40, 1255-1262 IF: 5.4 Download it! PDF format
  5. Prohászka, Z., Német, K., Csermely, P., Hudecz, F., Mezo, G. and Füst, Gy. (1997) Defensins purified from human granulocytes bind C1q and activate the classical complement pathway like the transmembrane glycoprotein gp41 of HIV-1. Molecular Immunology 34, 809-816 IF: 1.8 Download it! PDF format
1998
  1. Csermely, P. and Lakhotia, S.C. (1998) Molecular biology of stress responses in India. Cell Stress and Chaperones 3, 1-5
  2. Csermely, P. (1998) ?Hard Days on the Endless Frontier? Revisited. Comment. FASEB J. 12, 264
  3. Csermely, P., Schnaider, T. and Szántó, I. (1998) Possible nuclear functions of the major molecular chaperone of the eukaryotic cytoplasm, hsp90. Curr. Sci. 74, 442-445 Download it! PDF format
  4. Csermely, P. (1998) How can be 95 °C survived? World of Nature (Hung.) 129, 298-301
  5. Csermely, P., Schnaider, T., Sőti, Cs., Prohászka, Z. and Nardai, G. (1998) The 90 kDa molecular chaperone family: structure, function and clinical applications. A comprehensive review. Pharmacology and Therapeutics, 79, 129-168 IF: 7.7 Download it! PDF format
  6. Stress of life from molecules to man. (1998, Ed.: P. Csermely) Annals of the New York Academy of Sciences, vol. 851, pp. 547
  7. Sőti, Cs. and Csermely, P. (1998) Characterization of the nucleotide binding properties of the 90 kDa heat shock protein (hsp90). J. Biosci., 23, 347-352 IF: 0.4 Download it! PDF format
  8. Sőti, Cs., Radics, L., Yahara, I. and Csermely, P. (1998) Interaction of vanadate oligomers and molybdate with the 90 kDa heat shock protein, Hsp90. Eur. J. Biochem. 255, 611-617 IF: 3.3 Download it! PDF format
  9. Schnaider, T., Somogyi, J., Csermely, P. and Szamel, M. (1998) The hsp90-specific inhibitor, geldanamycin, inhibits CD28-mediated activation of human T lymphocytes. Life Sci. 63, 949-954 IF: 1.8 Download it! PDF format
  10. Mihály, K., Tóth, S., Szlávik, L. and Csermely, P. (1998) Attenuation of diabetic retinopathy by the molecular chaperone-inducer amino acid analogue, canavanine in streptozotocin diabetic rats. Cellular and Molecular Life Sciences (Experientia) 54, 1154-1160 IF: 2.9 Download it! PDF format
  11. Sőti, Cs. and Csermely, P. (1998) Molecular chaperones in the ethiology and therapeutics of cancer. Pathology Oncology Res. 4, 316-321 IF: 1.7
1999
  1. Csermely, P. (1999) Life at the freezing point? (Hung.). Természet Világa (Nature), 130, 108-112
  2. Szonyi, M., Csermely, P. and Sziklai, I. (1999) Acetylcholine and phosphorylation in isolated outer hair cells. Acta Otolar. (Stockh.) 119, 185-188 IF: 0.6
  3. Csermely, P., Gergely, P., Koltay T. and Tóth J. (1999) Research and publication in natural sciences: advices for beginers and professionals in science. (Hung.) Osiris Publishers, pp. 318 Download it! PDF format
  4. Csermely, P. (1999) Scientific research training for gifted children in Hungary. The Biochemist, June 1999, 21, 28-30
  5. Csermely, P. (1999) Limits of scientific growth. Science 284, 1622-1623 (letter) Download it! PDF format
  6. Henics, T., Nagy, E., Oh, H-J., Csermely, P., von Gabain, A. and Subjeck, J.R. (1999) Mammalian Hsp70 and Hsp110 proteins bind to RNA motifs involved in mRNA stability. J. Biol. Chem., 274: 17318-17324 IF: 7.7 Download it! PDF format
  7. Schnaider, T., Oikarinen, J., Hayasaka, H., Yahara, I. and Csermely, P. (1999) Interaction of Hsp90 with histones and related peptides. Life Sci., 65, 2417-2426 IF: 1.8 Download it! PDF format
  8. Csermely, P. (1999) The "chaperone-percolator" model: a possible molecular mechanism of Anfinsen-cage type chaperone action. BioEssays 21, 959-965 IF: 7.6 Download it! PDF format
  9. Csermely, P. (1999) Life in deep sea hydrothermal vents. (Hung.) Természet Világa (Nature), 130, 282-285
2000
  1. Schnaider, T., Somogyi, J., Csermely, P. and Szamel, M. (2000) The 90 kDa heat shock protein (Hsp90)-specific inhibitor, geldanamycin, selectively disrupts kinase-mediated signalimg events of T lymphocyte activation. Cell Stress and Chaperones 5, 52-61 IF: 2.9 Download it! PDF format
  2. Csermely, P. (2000) Crowding Stress. In: Encyclopedia of Stress. (Ed.: G. Fink) Academic Press. Vol.1. 601-603
  3. Csermely, P. (2000) Molecular chaperones: a novel self-defense.(Hung.) Természet Világa (Nature), 131, (Suppl. 1.)20-24
  4. Csermely, P. (2000) Alzheimer disease, Parkinson disease and prion infections as protein folding abnormalities (Hung.) Természet Világa (Nature), 131, 309-310
  5. Sőti, Cs. and Csermely, P. (2000) Why do we age? (Hung.) Természet Világa (Nature), 131, 352-356
  6. Csermely, P., Halász, G., Jeney, G., Máthé, J., Mikló, L., Solymári, D., Szekeres, Á., and Tamás, G. (2000) Research training between 14 and 18 in Hungary. Biochem. Education, 28, 132-133 Download it! PDF format
  7. DeFranco, D. and Csermely, P. (2000) Steroid receptor and molecular chaperone encounters in the nucleus. Science's Transduction Knowledge Environment http://www.stke.org/cgi/content/full/OC_sigtrans;2000/42/pe1
  8. Csermely, P., Sőti Cs., Schnaider, T., and Steták, A. (2000) Transfer of extracellular signals to the cell nucleus. (Hung.) Orvosképzés (Medical Education) 75, 30-38
  9. Schnaider T., Sőti Cs., Cheetham M. E., Miyata Y., Yahara I., Csermely P.: (2000) Interaction of the human DnaJ homologue GSJ1b with the 90 kDa heat shock protein, Hsp90. Life Sci., 67, 1455-1465 IF: 1.8 Download it! PDF format
  10. Sőti Cs. and Csermely, P. (2000) Molecular chaperones and aging process. Biogerontology, 1, 225-233 IF: 2.3 Download it! PDF format
  11. Csermely, P. (2000) Standards for the PhD degree in (life) sciences. Hungarian Science 107, 1272-1275
2001
  1. Nardai, G., Sass, B., Ebner, J., Orosz, Gy. and Csermely, P. (2001) Reactive cysteines of the 90 kDa heat shock protei, Hsp90. Arch. Biochem. Biophys,384, 59-67 IF: 2.6 Download it! PDF format
  2. Steták, A., Vántus, T., Bökönyi, G., Csermely, P., Vandenheede, J.R., Ullrich, A., Seprodi, J., Teplán, I. and Kéri, G. (2000) The antitumor somatostatin analogue (TT-232) induced signaling cascades, Peptides (eds: J. Martinez and J-A. Fehrentz) EDK, Paris, France, pp. 39-40
  3. Csermely, P. (2001) Chaperones as possible elements of eukaryotic cytoarchitecture. Biology International 40, 28-30
  4. Csermely, P. (2001) Stress proteins, Vince publishers, Science-University series, Budapest, pp. 224 Download it! PDF format
  5. Csermely, P. (2001) Stress proteins. Old and new concepts. Hungarian Science, 108, 129-135 http://www.matud.iif.hu/01feb/csermely.html
  6. Kiss, G., Heidegger, M., Somogyi, J., Csermely, P. and Ver, A. (2001) Streptozotocin-induced diabetes alters the oligomerization pattern of acetylcholinesterase in rat skeletal muscle. Diabetologia, 44, 220-223 IF: 5.1 Download it! PDF format
  7. Nardai, G., Braun, L., Csala, M., Mile, V., Csermely, P., Benedetti, A., Mandl, J. and Banhegyi, G. (2001) Protein disulfide isomerase and protein thiol dependent dehydroascorbate reduction and ascorbate accumulation in the lumen of the endoplasmic reticulum. J. Biol. Chem. 276, 8825-8828 IF: 6.7 Download it! PDF format
  8. Csermely, P. (2001) A nonconventional role of molecular chaperones: involvement in the cytoarchitecture. News in Physiological Sciences. 15, 123-126 IF: 2.7 Download it! PDF format
  9. Lifeline - Peter Csermely (2001) Lancet 358, 252 JPG
  10. Steták, A., Lankenau, A., Vántus, T., Csermely, P., Ullrich, A. and Kéri, Gy. (2001) The antitumor somatostatin analogue TT-232 induces cell cycle arrest through PKCd and c-Src. Biochem. Biophys. Res. Commun., 285, 483-488 IF: 2.9 Download it! PDF format
  11. Jermendy, Gy. and Csermely, P. (2001) Thiazolidindiones - a new group of oral antidiabetica. Medical Weekly (Hung.), 142, 1547-1554, the publication received the Lajos Markusovszky Award for the best publication of the journal in 2001
  12. Somogyi, J., Kiss, G., Pentek, E., Csermely, P. and Ver, A. (2001) Diabetes mellitus as a general membrane disease and its consequences. Medical Weekly (Hung.), 142, 1781-1788
  13. Csermely, P. (2001) Chaperone-overload as a possible contributor to "civilization diseases": atherosclerosis, cancer, diabetes. Trends in Genetics, 17, 701-704 IF: 13.2 Download it! PDF format
  14. Vántus, T., Kéri, G., Krivickiene, Z., Valius, M., Steták, A., Keppens, S., Csermely, P., Bauer, P.I., Bökönyi, G., Declercq, W., Vandenabeele, P., Merlevede, W., and Vandenheede, J.R. (2001) The somatostatin-analog TT-232 induces apoptosis in A431 cells: sustained activation of stress activated kinases and inhibition of signaling to Extracellular Signal-Regulated Kinases. Cell Signalling, 13, 717-725 IF: 4.3 Download it! PDF format
  15. Csermely, P. (2001) Water and cellular folding processes. Cell. Mol. Biol. 47, 791-800 IF: 1.7 Download it! PDF format
  16. Steták, A., Csermely, P., Ullrich A. and Kéri, Gy. (2001) Physical and functional interactions between protein tyrosine phosphatase a, PKCd and PI-3-kinase. Biochem. Biophys. Res. Comm., 288, 564-572 IF: 2.9 Download it! PDF format
2002
  1. Sőti, Cs., Rácz, A. and Csermely, P. (2002) A nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90: N-terminal nucleotide binding unmasks a C-terminal binding pocket. J. Biol. Chem. 277, 7066-7075 IF: 7.0 Download it! PDF format
  2. Nardai, G. and Csermely, P. (2002) Protein folding in diabetes. In: New Insights in Experimental Diabetes, ed.: D. Cheta, Romanian Academy Publishing House, Bucharest., pp. 120-131.
  3. Dénes, L., Jednákovits, A., Hargitai, J., Pénzes, Z., Balla, A., Krajcsi, P., Tális, L. and Csermely, P. (2002) BRX-235 mediates the migration of aortic endothelial cells through the p38 SAPK. Br. J. Pharmacol. 136, 597-603 IF: 3.5 Download it! PDF format
  4. Csermely, P. (2002) Changes of metabolism in diabetes mellitus. In: Diabetes mellitus - Theory and Clinics. (Eds.: T. Halmos and G. Jermendy) 3rd edition, Medicina Publishers, Budapest, pp. 91-98.
  5. Csermely, P. (2002) Effects of insulin on carbohydrate, lipid and protein metabolism. In: Diabetes mellitus - Theory and Clinics. (Eds.: T. Halmos and G. Jermendy) 3rd edition, Medicina Publishers, Budapest, pp. 127-131.
  6. Kalmár, B., Burnstock, G., Vrbova, G., Urbanics, R., Csermely, P. and Greensmith, L. (2002) Upregulation of heat shock proteins rescues motoneurones from axotomy-induced cell death in neonatal rats. Exp. Neurol., 176, 87-97. IF: 3.6 Download it! PDF format
  7. Sőti Cs. and Csermely, P. (2002) Chaperones come of age. Cell Stress and Chaperones 7, 186-190. IF: 2.9 Download it! PDF format
  8. Sőti, Cs. and Csermely, P. (2002) Chaperones and aging: their role in neurodegeneration and other civilizational diseases. Neurochem. International., 41, 383-389. IF: 2.9 Download it! PDF format
  9. Csermely, P. (2002) Scientific research training for gifted high school students in Hungary. Gifted Education International 17, 92-96.
  10. Szántó, S., Csermely, P., Kovács, I., Csongor, J., Illes, A., Bako, G., Szegedi, Gy. and Sipka, S. (2002) Inhibition of arachidonic acid release from human peripheral mononuclear cells by heat shock treatment and geldanamycin. Immunology Lett. 83, 181-185 IF: 1.8 Download it! PDF format
  11. Nardai, G., Csermely, P. and Sőti, Cs. (2002) Chaperone function and chaperone overload in the aged, Exp. Gerontol, 37, 1255-1260 IF: 3.5 Download it! PDF format
  12. Nardai G., Korcsmáros, T. and Csermely, P. (2002) Reduction of the endoplasmic reticulum accompanies the oxidative damage of diabetes mellitus, In: Redox regulation (eds.: A. Pompella, G. Banhegyi and M. Wellman-Rousseau), NATO Science Series, I/347, 281-289.
  13. Csermely, P., Nardai, G. and Sőti, Cs. (2002) Redox regulation in protein folding and chaperone function, In: Redox regulation (eds.: A. Pompella, G. Banhegyi and M. Wellman-Rousseau), NATO Science Series, I/347, 273-280.
  14. Csermely, P. and Yahara, I. (2002) Heat shock proteins. In: Molecular Pathomechanisms and New Trends in Drug Research (Eds.: Gy. Kéri and I. Tóth), Taylor and Francis, London and New York, pp. 67-75. Download it! PDF format
2003
  1. Fábián, T.K., Gáspár, J., Fejérdy, L., Tóth, Z., Bálint, M., Csermely, P. and Fejérdy, P. (2003) Hsp70 is secreted to human saliva, Med. Sci. Monitor 9, BR62-BR65. Download it! PDF format
  2. Csermely, P. and Lederman, L. (eds., 2003) Science Education: Talent Recruitment and Public Understanding, NATO Science Series, vol. V/38. IOS Press
  3. Csermely, P., Borsodi, Z., Korcsmáros, T. and Pato, B. (2003) Six Years of Scientific Research Training in Hungary. Progress, Plans, Problems. In: Science Education: Talent Recruitment and Public Understanding, (Csermely, P. and Lederman, L. eds.) NATO Science Series, vol. V/38. pp. 191-198.
  4. Sőti, Cs., Sreedhar, A.S. and Csermely, P. (2003) Apoptosis, necrosis and cellular senescence: chaperone occupancy as a potential switch. Aging Cell 2, 39-45. IF: 2.1Download it! PDF format
  5. Török, Zs., Tsvetkova, N.M., Balogh, G., Horváth, I., Nagy, E., Pénzes, Z., Hargitai, J., Bensaude, O., Csermely, P., Crowe, J.H., Maresca, B. and Vígh, L. (2003) Heat shock protein co-inducers with no effect on protein denaturation specifically modulate the membrane lipid phase. Proc. Natl. Acad. Sci. USA 100, 3131-3136 IF: 10.3 Download it! PDF format
  6. Hargitai, J., Lewis, H. Boros, I., Rácz, T., Fiser, A., Kurucz, I., Benjamin, I., Pénzes, Z., Vígh, L., Csermely, P. and Latchman, D.S. (2003) Bimoclomol, a heat shock protein co-inducer acts by the prolonged activation of heat shock factor-1 (HSF-1). Biochem. Biophys. Res. Commun. 307, 689-695 IF: 2.9 Download it! PDF format
  7. Papp, E., Nardai, G., Sőti, Cs. and Csermely, P. (2003) Molecular chaperones, stress proteins and redox homeostasis. Biofactors 17, 249-257, IF: 1.8 Download it! PDF format
  8. Nardai G., Korcsmáros, T., Papp, E. and Csermely, P. (2003) Reduction of the endoplasmic reticulum accompanies the oxidative damage of diabetes mellitus. Biofactors 17, 259-267, IF: 1.8 Download it! PDF format
  9. Sreedhar, A.S., Mihály, K., Pató, B., Schnaider, T., Steták, A., Kis-Petik, K., Fidy, J., Simonics, T., Maráz, A. and Csermely, P. (2003) Hsp90 inhibition accelerates cell lysis: anti-Hsp90 ribozyme reveals a complex mechanism of Hsp90 inhibitors involving both superoxide- and Hsp90-dependent events. J. Biol. Chem. 278, 35231-35240, IF: 6.6 Download it! PDF format
  10. Csermely, P. (2003) Recruitment of the youngest generation to science. A Network of Youth Excellence and communication strategies for high school student researchers. EMBO Rep. 4, 825-828, IF: 7.7 Download it! PDF format
  11. Jermendy, Gy. and Csermely, P. (2003) The role of benfotiamine in the pathomechanism and therapy of late diabetic complications: Experimental and clinical data Arch. Internist (Hung.) 56, 131-136.
  12. Sőti, Cs. and Csermely, P. (2003) Ageing and molecular chaperones. Exp. Gerontol. 38, 1037-1040, IF: 3.5 Download it! PDF format
  13. Ishiwatari-Hayasaka, H., Maruya, M., Sreedhar, A.S., Nemoto, T., Csermely, P. and Yahara, I.(2003) Interaction of neuropeptide Y and Hsp90 through a novel peptide binding region. Biochemistry 42, 12972-12980, IF: 4.2 Download it! PDF format
  14. Kalmár, B., Greensmith, L., Malcangio, M., MacMahon, S.B., Csermely, P. and Burnstock, G. (2003) The effect of treatment with BRX-220, a co-inducer of heat shock proteins, on sensory fibres of the rat following peripheral nerve injury. Exp. Neurol., 184(2):636-647 IF: 3.6 Download it! PDF format
  15. Sreedhar, A.S. and Csermely, P. (2003) Novel roles of Hsp90 inhibitors and Hsp90: redox regulation and cytoarchitecture. Rec. Res. Dev. Life Sci. 1, 153-171
  16. Sőti, Cs., Vermes, A., Haystead, T.A. and Csermely, P. (2003) Comparative ananlysis of the N- and C-terminal ATP-binding sites of Hsp90:a distinct nucleotide specificty of the C-terminal ATP-binding site. Eur. J. Biochem. 270, 2421-2428, IF: 3.0 Download it! PDF format
  17. Papp, E., Korcsmáros, T., Nardai G., and Csermely, P. (2004) Changes of cellular redox homeostasis and protein folding in diabetes, In: Cellular dysfunction in atherosclerosis and diabetes - Reports from bench to bedside (eds.: M. Simionescu, A. Sima, D. Popov), Plenum Press, 228-235 Download it! PDF format
  18. Csermely, P., Sőti Cs., Kalmár, E., Papp, E., Pato, B., Vermes,A. and Sreedhar, A.S. (2003) Molecular chaperones, evolution and medicine. J. Mol. Struct. Theochem, 666-667, 373-380 IF: 1.0 Download it! PDF format
  19. Somogyi, J., Szalay, J., Pándics, T., Rosta, K., Csermely, P. and Vér, Á. (2003) New steroid hormone family: the endogenous cardiac glycosides and their role in the organism under physiological and pathological conditions. Medical Weekly (Hung.), 145, 259-266
2004
  1. Sreedhar, A.S., Sőti, Cs. and Csermely, P. (2004) Inhibition of Hsp90: a new strategy for inhibiting protein kinases. Biochim. Biophys. Acta, 11; 1697 (1-2): 233-242 IF: 2.8 Download it! PDF format
  2. Sreedhar, A.S. and Csermely, P. (2004) Heat shock proteins in the regulation of apoptosis. A comprehensive review. Pharmacology and Therapeutics, 101(3): 227-257 Download it! PDF format IF: 5.6
  3. Kalmár, B., Greensmith, L., Malcangio, M., MacMahon, S.B., Csermely, P. and Burnstock, G. (2003) The effect of treatment with BRX-220, a co-inducer of heat shock proteins, on sensory fibres of the rat following peripheral nerve injury. Exp. Neurol., 184(2):636-647 IF: 3.6 Download it! PDF format
  4. Fábián, T.K., Tóth, Zs., Fejérdy, L., Gáspár, J., Kaán, B., Csermely, P. and Fejérdy, P. (2004) Photo-acoustic stimulation increases the Hsp70 content of human whole saliva. Initial studies. Int. J. Psychophysiol., 52, 211-216 IF: 1.5 Download it! PDF format
  5. Varsányi, M., Szarka, A., Papp, E., Makai, D., Nardai, G., Fulceri, R., Csermely, P., Mandl, J., Benedetti, A. and Bánhegyi, G. (2004) FAD transport and FAD-dependent protein thiol oxidation in rat liver microsomes. J. Biol. Chem.279, 3370-3374, IF: 6.7 Download it! PDF format
  6. Sreedhar, A.S., Nardai, G. and Csermely, P. (2004) Enhancement of complement-induced cell lysis: a novel mechanism for the anticancer effects of Hsp90 inhibitors. Immunol. Lett. 92, 157-161, IF: 1.8 Download it! PDF format
  7. Sreedhar, A.S., Kalmár, E., Csermely, P. and Shen, Y. F. (2004) Hsp90 isoforms: functions, expression and clinical importance. FEBS Lett. 562, 11-15, IF: 3.4 Download it! PDF format
  8. Csermely, P. (2004) Strongs links are important - but weak links stabilize them. Trends in Biochem. Sci., 29, 331-334, IF: 14.4 Download it! PDF format
  9. Tompa P. and Csermely P. (2004) The role of structural disorder in RNA- and protein chaperone function. FASEB J., 18, 1169-1175 IF: 7.2 Download it! PDF format
  10. Papp, E., Nardai, G., Sreedhar, A.S., Korcsmáros, T. and Csermely, P. (2005) Effects of unfolded protein accumulation on the redox state of the endoplasmic reticulum, In: Redox regulation (eds.: A. Pompella, G. Banhegyi and M. Wellman-Rousseau), NATO Science Series, vol. 111-119.
  11. Nardai, G., Papp, E., Korcsmáros, T., Stadler, K., Jakus, J. and Csermely, P. (2005) Possible links between metabolism and oxidative protein folding. Conseqences of a diabetes study, In: Redox regulation (eds.: A. Pompella, G. Banhegyi and M. Wellman-Rousseau), NATO Science Series, vol. 363, 101-109.
  12. Farkas, A., Nardai, G., Csermely, P., Tompa, P. and Friedrich, P. (2004) DUK114, the drosophila homolog of bovine brain calpain activator protein, is a molecular chaperone. Biochem J.383, 165-170 IF: 4,6 Download it! PDF format
  13. Fejérdy, L., Tóth, Zs., Kaán, B., Fábián, T.K., Csermely, P. and Fejérdy, P. (2004) Effect of local heat- and mechanical stress (massage) on the molecular chaperone (Hsp70) concentration of mixed human saliva. Preliminary data. Dental Review (Hung.) 97, 204-210.
  14. Kabakov, A.E., Budagova, K.R., Malyutina, Y.V., Latchman, D.S. and Csermely, P. (2004) Pharmacological attenuation of apoptosis in reoxygenated endothelial cells. Cell. Mol. Life Sci. 61, 3076-3086, IF: 5.0 Download it! PDF format
  15. Csermely, P. (2004) The strength of weak links: from stress proteins to social networks. Hungarian Science 111, 1318-1324 (in Hungarian) http://www.matud.iif.hu/04dec/01.html
2005
  1. Kovács, I.A., Szalay, M.S. and Csermely, P. (2005) Water and molecular chaperones act as weak links of protein folding networks: energy landscape and punctuated equilibrium changes point towards a game theory of proteins. FEBS Letters, 579, 2254-2260 IF: 3.5 Download it! PDF format
  2. Sőti, Cs., Pal, Cs., Papp, B. and Csermely, P. (2005) Chaperones as regulatory elements of cellular networks. Curr. Op. Cell Biol. 17, 210-215 IF: 18.2 Download it! PDF format
  3. Agoston, V., Csermely, P. and Pongor, S. (2005) Multiple, weak hits confuse complex systems: A transcriptional regulatory network as an example Phys.Rev. E 71, 051909 Download it! PDF format IF: 2.2
  4. Csermely, P., Ágoston, V. and Pongor, S. (2005) The efficiency of multi-target drugs: the network approach might help drug design. Trends Pharmacol. Sci. 26,178-182 Download it! PDF format IF: 14.0
  5. Csermely, P., Korcsmáros, T. and Lederman, L. (eds., 2005) Science Education: Talent Recruitment and Public Understanding, NATO Science Series, IOS Press, vol. V/47, pp. 235
  6. Csermely, P. (2005) The strength of hidden networks. Weak links as universal keys for diversity and stability, Vince publishers, Science-University series, Budapest, pp. 376, see the downloadable chapters here: www.weaklink.sote.hu/halozat.html
  7. Sőti, Cs. and Csermely, P. (2005) Pharmacological modulation of the heat shock response. In: Molecular Chaperones in Health and Disease (ed.: M. Gaestel). Springer Verlag, Handbook of Experimental Pharmacology 172: 417-436
  8. Papp, E. and Csermely, P. (2005) Chemical, Pharmacological and other small-molecule chaperones - Mechanism of action and potential use. In: Molecular Chaperones in Health and Disease (ed.: M. Gaestel). Springer Verlag, Handbook of Experimental Pharmacology 172: 405-416
  9. Nardai G., Stadler, K., Papp, E., Korcsmáros, T. Jakus, J., and Csermely, P. (2005) Diabetic changes in the redox status of the microsomal protein folding machinery. Biochemical and Biophysical Research Communications 334, 787-795 IF: 3.0 Download it! PDF format
  10. Papp, E., Nardai, G., Mandl, J., Banhegyi, G. and Csermely, P. (2005) FAD oxidizes the Ero1-PDI electron transfer chain: The role of membrane-integrity. Biochem. Biophys. Res. Commun. 338, 938-945 IF: 3.0 Download it! PDF format
  11. Csermely, P. (2005, re-print: 2008) The strength of hidden networks. Weak links as universal keys for diversity and stability, Vince publishers, Science-University series, Budapest, pp. 376
2006
  1. Csermely, P. (2006): Heat shock proteins in brain function. In: Handbook of Neurochemistry (Ed.: A. Lajtha and R. Lin), Springer Verlag vol. 9, pp. 271-287.
  2. Nardai, G., Vegh, E., Prohaszka, Z. and Csermely, P. (2006) Chaperone-related immune dysfunctions: An emergent property of distorted chaperone-networks. Trends Immunol. 27, 74-79 IF: 10.2 Download it! PDF format suppl. mat Download it! PDF format
  3. Daniel, S., Sőti, C., Csermely, P., Bradley, G. and Blatch, G. (2006) Hop: an Hsp70/90 chaperone that functions within and beyond Hsp70-Hsp90 folding pathways. In: Co-chaperones (Ed.: G. Blatch) Springer Verlag. pp. 26-37. Download it! PDF format
  4. Csermely, P. and Vígh, L. (eds., 2006) Molecular Aspects of the Stress Response: chaperones, membranes and networks, Advances in Experimental Medicine and Biology, vol. 594. Springer Science+Business Media, LCC and Landes Bioscience / Eurekah.com, pp. 201.Download it! PDF format
  5. Sőti, C, Nagy, E, Giricz, Z, Vígh. L, Csermely, P, and Ferdinandy, P, (2006) Heat shock proteins as emerging therapeutic targets. Br. J. Pharmacol. 146, 769-780 IF: 3.6 Download it! PDF format
  6. Piccirella, S., Czegle, I., Lizák, B., Margittai, E., Senesi, S., Papp, E., Csala, M., Fulceri, R., Csermely, P., Mandl, J., Benedetti, A. and Bánhegyi, G. (2006) Uncoupled redox systems in the lumen of the endoplasmic reticulum: Pyridine nucleotides stay reduced in an oxidative environment. J. Biol. Chem. 281, 4671-4677 IF: 5.8 Download it! PDF format
  7. Pál, C., Papp, B., Lercher, M.J., Csermely, P., Oliver, S.G. and Hurst, L.D. (2006) Chance and necessity in the evolution of minimal metabolic networks. Nature 440, 667-670 IF: 26.7 Download it! PDF format suppl Download it! PDF format
  8. Papp, E., Száraz, P., Korcsmáros, T., Csermely, P. (2006) Changes of endoplasmic reticulum chaperone complexes, redox state and impaired protein disulfide reductase activity in misfolding alpha-1-antitrypsin transgenic mice. FASEB J. 20, 1018-1020 IF: 6.7 Download it! PDF format
  9. Csermely, P. and Sőti, C. (2006) Cellular networks and the aging process. Arch. Physiol. Biochem. 112, 60-64 Download it! PDF format
  10. Csermely, P., Blatch, G. and Sőti, C. (2006) Chaperones as parts of cellular networks. In: (Eds.: P. Csermely and L. Vígh) Molecular aspects of the stress response: chaperones, membranes and network, Advances in Experimental Medicine and Biology vol. 594. Springer Science+Business Media, LCC and Landes Bioscience / Eurekah.com pp. 55-63. IF: 0.6, Download it! PDF format
  11. Rutherford, S. L., Knapp, J. R. and Csermely, P. (2006) Hsp90 and developmental networks. In: (Eds.: P. Csermely and L. Vígh) Molecular aspects of the stress response: chaperones, membranes and network, Advances in Experimental Medicine and Biology vol. 594. Springer Science+Business Media, LCC and Landes Bioscience / Eurekah.com pp. 190-198. IF: 0.6 Download it! PDF format
  12. Csermely, P., Korcsmáros, T., Kovács, I. and Szalay, M. (2006) Method for analyzing the fine structure of networks. Patent application WO2007093960.
  13. Arslan, MA, Csermely, P. and Sőti, Cs. (2006) Protein homeostasis and molecular chaperones in aging. Biogerontology 7, 383-389 Download it! PDF format IF: 3.1
  14. Csermely, P. and Sőti, Cs. (2006) Aging from a network perspective. Hungarian Science 167, 1309-1312 (in Hungarian). http://www.matud.iif.hu/06nov/04.html
  15. Fábián, T.K., Müller, O., Fejérdy, P. and Csermely, P. (2006) Citation graphs in network studies. Kis Táska (Small-Bag) 4, 8-10 (in Hungarian).
2007
  1. Csermely, P. (2006, re-print: 2007, 2nd paperback edition: 2009) Weak links: Stabilizers of Complex Systems from Proteins to Social Networks, Springer Verlag, pp. 392, see the downloadable chapters here: www.weaklink.sote.hu/weakbook.html The Google version of the book: http://books.google.com/books?id=bu34G3A2E9YC
    Comments and availability of the book can be found here
  2. Csermely, P., Korlevic, K. and Sulyok, K. (eds., 2007) Science Education: Models and Networking of Student Research Training under 21, NATO Security through Science Series, Human and Societal Dynamics E, vol. 16, IOS Press, pp. 303
  3. Csermely, P., Korcsmáros, T. and Sulyok, K. (eds., 2007) Stress Responses in Biology and Medicine: Stress of Life in Molecules, Cells, Organisms, and Psychosocial Communities. Annals of the New York Academy of Sciences, vol. 1113, pp. 366.
  4. Csermely, P. and Sőti, C. (2007) Aging cellular networks: chaperones as major participants. Exp. Gerontol. 42, 113-119 (www.arxiv.org/q.bio.MN/0605030) IF: 2.9 Download it! PDF format
  5. Fábián, T.K., Fejérdy, P., Nguyen, M.T., Sőti, C. and Csermely, P. (2007) Potential immunological functions of salivary Hsp70 in mucosal and periodontal defense mechanisms. Arch. Imm. Ther. Exp. 55, 1-8, IF: 1.6 Download it! PDF format
  6. Korcsmáros, T., Kovács, I.A., Szalay, M.S. and Csermely, P. (2007) Molecular chaperones: the modular evolution of cellular networks. J. Biosci. 32, 441-446, arxiv.org/q-bio.MN/0701030, IF: 1.0 Download it! PDF format
  7. Sőti, C. and Csermely, P. (2007) Protein stress and stress proteins: implications in aging and disease. J. Biosci. 32, 511-515, IF: 1.0 Download it! PDF format
  8. Korcsmáros, T., Szalay, M.S., Böde. C., Kovács, I.A., and Csermely, P. (2007) How to design multi-target drugs: Target-search options in cellular networks. Expert Op. Drug Discov. 2, 1-10, arxiv.org/q-bio.MN/0703010. Download it! PDF format
  9. Böde. C., Kovács, I.A., Szalay, M.S., Palotai, R. Korcsmáros, T., and Csermely, P. (2007) Network analysis of protein dynamics. FEBS Lett. 581, 2776-2782, arxiv.org/q-bio.BM/0703025, IF: 3.4 Download it! PDF format
  10. Szalay, M.S., Kovács, I.A., Korcsmáros, T., Böde. C. and Csermely, P. (2007) Stress-induced rearrangements of cellular networks: consequences for protection and drug design. FEBS Lett. 581, 3675-3680, arxiv.org/q-bio.MN/0702006, IF: 3.4 Download it! PDF format
  11. Csermely, P. (2007) The pathobiochemistry of the nucleus. In: Medical Pathobiochemistry (Eds.: J. Mandl and R. Machovich) Medicina, Budapest, Hungary, pp. 262-264.
  12. Sőti, Cs. and Csermely, P. (2007) Biogerontology - the (patho)biochemistry of aging. In: Medical Pathobiochemistry (Eds.: J. Mandl and R. Machovich) Medicina, Budapest, Hungary, pp. 607-622
  13. Tompa, P. and Csermely, P. (2007) Pathological proteins, protein folding diseases. In: Medical Pathobiochemistry (Eds.: J. Mandl and R. Machovich) Medicina, Budapest, Hungary, pp. 61-74
  14. Vér, Á. and Csermely, P. (2007) Metabolic syndrome, obesity, diabetes mellitus. In: Medical Pathobiochemistry (Eds.: J. Mandl and R. Machovich) Medicina, Budapest, Hungary, pp. 455-478
  15. Kovács, L. and Csermely, P. (2007) Crowding Stress. In: Encyclopedia of Stress. (Ed.: G. Fink, 2nd Ed.) Academic Press. pp. 669-672 Download it! PDF format
  16. Csermely, P. and Fábián T.K. (2007) Properties of complex systems in psychosomatic diseases. In: (G. Vértes and T.K. Fábián ed.) Dental psychosomatics, Medicina, Budapest, Hungary, pp. 61-71.
  17. Steták, A., Veress, R. Ovádi, J., Csermely, P., Kéri, G. and Ullrich, A. (2007) Nuclear translocation of the tumor marker Pyruvate-Kinase M2 induces programmed cell death. Cancer Res. 67, 1602-1608, IF: 7.7 Download it! PDF format
  18. Kovács, Sz., Fábián, T. K., Gaál, V. and Csermely, P. (2007) Effect of social network parameters on anxiety: A pilot study on a 14-18 years high school student population. Hungarian Psychol. Bulletin 62, 193-201. Download it! PDF format
  19. Fábián, G., Müller, O., Kovács, Sz., Nguyen, M-T., Fábián, T.K., Csermely, P. and Fejerdy P. (2007) Attitude towards death. Does it influence dental fear? Ann. NY Acad Sci. 1113, 339-349, IF: 1.9 Download it! PDF format
2008
  1. Putics, Á, Végh, E.M., Csermely, P. and Sőti, C. (2008) Resveratrol induces the heat shock response and protects human cells from severe heat stress. Antiox. Redox Signaling 10, 65-76, IF: 4.5 Download it! PDF format
  2. Wang, S., Szalay, M.S., Zhang, C. and Csermely, P. (2008) Learning and innovative elements of strategy update rules expand cooperative network topologies. PLoS One 3, e1917, Visit it at arxiv.org!
    Download it! PDF format
  3. Putics, Á., Vörös, D., Malavolta, M., Mocchegiani, E., Csermely, P. and Sőti, C. (2008) Zinc supplementation boosts the stress response in the elderly:Hsp70 status is linked to zinc availability in peripheral lymphocytes. Exp. Gerontol. 43, 452-461. IF: 2.9Download it! PDF format
  4. Fábián, T.K., Fejérdy, P. and Csermely, P. (2008) Salivary genomics, transcriptomics and proteomics: the emerging concept of the oral ecosystem and their use in the early diagnosis of cancer and other diseases. Curr. Genomics. 9, 11-21, IF: 0.8 Download it! PDF format
  5. Palotai, R. Szalay, M.S. and Csermely, P. (2008) Chaperones as integrators of cellular networks: changes of cellular integrity in stress and diseases. IUBMB Life 60, 10-18, arxiv.org/0710.1622, IF: 2.3 Download it! PDF format
    Visit it at arXiv.org!
  6. Csermely, P., Korcsmáros, T., Kovács, I.A., Szalay M.S. and Sőti, C. (2008) Systems biology of molecular chaperone networks. In: The biology of extracellular molecular chaperones. Novartis Foundation Symposium Series Vol. 291, Wiley, pp. 45-58. Download it! PDF format
  7. Fábián, T.K., Fejerdy P. and Csermely, P. (2008) Chemical biology of saliva in health and disease. In: Wiley Encyclopedia of Chemical Biology (Ed. T.P. Begley) John Wiley & Sons, New York, doi: 10.1002/9780470048672.wecb643 Download it! PDF format
  8. Daniel, S. Bradley, G., Longshaw, V. M., Söti, C., Csermely, P. and Blatch, G. L. (2008) Nuclear translocation of the phosphoprotein Hop (Hsp70/Hsp90 organizing protein) occurs under heat shock, and its proposed nuclear localization signal is involved in Hsp90 binding. BBA Mol. Cell. Res. 1783, 1003-1014. IF: 6,9 Download it! PDF format
  9. Spiro, Z., Kovács I.A. and Csermely, P. (2008) Insights from networks of drugs, therapies, targets and diseases and the prediction of novel drug targets. J. Biol. 7, 20.
    Visit the extended version at arXiv.org!
     Download it! PDF format
  10. Csermely, P. (2008) A network scientists highlights active sites of enzymes, cells, brains and the society. Nature 454, 5 Download it! PDF format
  11. Csermely, P. (2008) Creative elements: network-based predictions of active centres in proteins, cellular and social networks. Trends Biochem. Sci. 33, 569-576. IF: 15.0 Download it! PDF format
    Visit it at arXiv.org!
  12. Fábián, T.K., Sőti, C., Minh Tu, N., Csermely, P. and Fejérdy, P. (2008) Expected functions of salivary Hsp70 in the oral cavity. In: Heat shock proteins – New Research (Eds.: E. Morel C. Vincent). Nova Science Publishers, New York. pp. 321-340.
2009
  1. Sőti, Cs. and Csermely, P. (2009) Cellular senescence. In: (Ed.: Szabó G.) Cell Biology, Medicina, Budapest, Hungary, pp. 579-588
  2. Antal, M.A., Böde, C. and Csermely, P. (2009) Perturbation waves in proteins and protein networks: Applications of percolation and game theories in signaling and drug design. Curr. Prot. Pept. Sci. 10, 161-172, IF: 3.3.
    Download it! PDF format
  3. Kiss H.J.M., Mihalik, Á., Nánási, T. Ory, B., Spiró, Z., Sőti, C. and Csermely, P. (2009) Ageing as a price of cooperation and complexity: Self-organization of complex systems causes the ageing of constituent networks. Bio Essays 31, 651-664. IF: 5.4 Visit it at arXiv.org! Available from Nature Precedings
    Download it! PDF format
  4. Fábián TK, Csermely, P., Fábián G. and Fejérdy P. (2009) Spondyloarthopathies and bone resorption: a possible role of heat shock protein (Hsp70). Review. Acta Physiol. Hung. 96, 149-155.Download it! PDF format
  5. Palotai, R. and Csermely, P. (2009) Network modules help the identification of key transport routes, signaling pathways in cellular and other networks. Annalen der Physik 18, 822-829, www.arxiv.org/0908.4524
    Download it! PDF format
  6. Simkó, G. I., Gyurkó, D., Veres, D. V., Nánási, T. and Csermely, P. (2009) Network strategies to understand the aging process and help age-related drug design. www.arxiv.org/0908.4508 Genome Medicine 1, 90
    Download it! PDF format
2010
  1. Kovács, I.A., Palotai, R., Szalay, M.S. and Csermely, P. (2010) Community landscapes: a novel, integrative approach for the determination of overlapping network modules. PLoS ONE 7, e12528, IF: 4.4 Download it! PDF format
    www.arxiv.org/abs/0912.0161 Supporting web-site with all downloadable algorithms: www.linkgroup.hu/modules.php
    Featured in the February 2011 issue of Science Signaling
  2. Dancsó, B., Spiró, Z., Arslan, M.A., Minh Tú, N., Papp, D., Csermely, P. and Sőti, C. (2010) The heat shock connection of metabolic stress and dietary restriction. Curr. Pharm. Biotech. 11, 139-145 IF: 2.6 Download it! PDF format
  3. Tamás Korcsmáros; Illés J. Farkas; Máté S. Szalay; Petra Rovó; Dávid Fazekas; Zoltán Spiró; Csaba Böde; Katalin Lenti; Tibor Vellai; Péter Csermely (2010) Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery. Bioinformatics 26, 2042-2050, IF: 4,9; Download it! PDF format
    Supplementary material PDF format
  4. Csermely, P., Palotai, R. and Nussinov, R. (2010) Induced fit, conformational selection and independent dynamic segments: an extended view of binding events. Trends Biochem. Sci. 35, 539-546, IF: 11.6, http://arxiv.org/abs/1005.0348 -- a cover story. Download it! PDF format
2011
  1. Nussinov, R., Tsai, C.-J. and Csermely, P. (2011) Allo-network drugs: harnessing allostery in cellular networks. Trends in Pharmacol. Sci. 32, 686-693, IF: 11.0 -- a cover story. Download it! PDF format
  2. Korcsmáros, T. Szalay, M.S., Rovó, P., Palotai, R., Fazekas, D., Lenti, K., Farkas, I.J. Csermely, P. and Vellai, T. (2011) Signalogs: orthology-based identification of novel signaling pathway components in three metazoans. PLoS ONE 8, e19240, IF: 4,4 Download it! PDF format
  3. Farkas, I.J., Korcsmáros, T., Kovács, I.A., Mihalik, Á., Palotai, R., Simkó, G.I., Szalay, K.Z., Szalay-Bekő, M., Vellai, T., Wang, S. and Csermely, P. (2011) Network-based tools in the identification of novel drug-targets. Science Signaling 4, pt3. IF: 6.120 Download the paper! PDF format
    Download the slideshow!
  4. Mihalik, Á. and Csermely, P. (2011) Heat shock partially dissociates the overlapping modules of the yeast protein-protein interaction network. PLoS Comput. Biol. 7, e1002187, IF: 5.5 Download it! PDF format
    http://arxiv.org/abs/1105.2933
2012
  1. Csermely, P., Sandhu, K.S., Hazai, E., Hoksza, Z., Kiss, H.J.M., Miozzo, F. Veres, D.V., Piazza, F. and Nussinov, R. (2012) Disordered proteins and network disorder in network representations of protein structure, dynamics and function. Hypotheses and a comprehensive review. Curr. Prot. Pept. Sci. 13, 19-33, IF: 3,9, http://arxiv.org/abs/1101.5865
    Download it! PDF format
  2. Arslan, M.A., Chikina, M. Csermely, P. and Sőti, C, (2012) Misfolded proteins inhibit proliferation and promote stress-induced death in SV40-transformed mammalian cells. FASEB J. 26, 766-777, IF: 6.5 Download it! PDF format
  3. Szalay-Bekő, M., Palotai, R., Szappanos, B., Kovács, I.A., Papp, B. and Csermely, P. (2012) ModuLand plug-in for Cytoscape: extensively overlapping modules, community centrality and their use in biological networks. http://arxiv.org/abs/1111.3033
    Download it! PDF format
    The Cytoscape plug-in program and its User Guide can be downloaded from here: http://www.linkgroup.hu/modules.php
  4. Spiró, Z. Arslan, M.A., Somogyvári, M., Nguyen, M.T., Smolders, A., Dancsó, B., Németh, N., Elek, Z., Braeckman, B., Csermely, P. and Sőti, C. (2012) RNA interference links oxidative stress to the inhibition of heat stress adaptation. Antiox. Redox Signaling, in press, IF: 8.2
    Download it! PDF format
  5. Papp, D., Csermely, P. and Sőti, C. (2012) A role for SKN-1/Nrf in pathogen resistance and immunosenescence in Caenorhabditis elegans. PLoS Pathogens 8, e1002673, IF: 9.1 , Download it! PDF format
  6. Hegedus, T., Gyimesi, G., Gáspár, E.M., Szalay, K.Z., Kellermayer, M.S.Z., Sarkadi, B. and Csermely, P. (2012) Role of network descriptions in the protonation states and conformational changes of ABC transporters. Curr. Pharm. Des. in press, IF: 4.8
  7. Gáspár, E.M. és Csermely, P. (2012) Rigidity and flexibility of biological networks. Briefings Funct. Genomics, invited review, http://arxiv.org/abs/1204.6389
    Download it! PDF format
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