This project is based on the expertise of the Pál-Papp duo on flux-balance analysis and combines this knowledge with their recent advances in high-throughput experimental techniques on in vitro evolution of single-cell organisms. The robustness of cellular networks is planned to be tested using the above complex methodology in conjunction of the development of novel approaches in drug design strategies.
- Szalay-Bekő, M., Palotai, R., Szappanos, B., Kovács, I.A., Papp, B. and Csermely, P. (2012) ModuLand plug-in for Cytoscape: extensively overlapping modules, community centrality and their use in biological networks. Bioinformatics, in press http://arxiv.org/abs/1111.3033
The Cytoscape plug-in program and its User Guide can be downloaded from here: http://www.linkgroup.hu/modules.php
- Papp, B., Pal, C. and Hurst, L. D. (2004) Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast. Nature 429, 661-664.
- Hurst, L.D. and Pal, C. (2005) Dissecting dispensability. Nature Genet. 37, 214-215.
- Pal, C., Papp, B. and Lercher, M.J. (2005) Adaptive evolution of bacterial metabolic networks by horizontal gene transfer. Nature Genet. 37, 1372-1375
- Pál, C., Papp, B., Lercher, M.J., Csermely, P., Oliver, S.G. and Hurst, L.D. (2006) Chance and necessity in the evolution of minimal metabolic networks. Nature 440, 667-670 paper
- Harrison, R., Papp, B., Pal, C., Oliver, S.G. and Delneri, D. (2007) Plasticity of genetic interactions in metabolic networks of yeast. Proc. Natl. Acad. Sci. USA 104, 2307-2312