Summary: The ModuLand method-family

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Background: Network communities help the functional organization and evolution of complex networks. However, the development of a method, which is both fast and accurate, provides modular overlaps and partitions of a heterogeneous network, has proven to be rather difficult.

Methodology/Principal Findings: Here we introduce the novel concept of ModuLand and its plug-in to the widely used Cytoscape progam, an integrative method family determining overlapping network modules as hills of an influence function-based, centrality-type community landscape, and including several widely used modularization methods as special cases. As various adaptations of the method family, we developed several algorithms, which provide an efficient analysis of weighted and directed networks, and (1) determine overlapping modules with high resolution; (2) uncover a detailed hierarchical network structure allowing an efficient, zoom-in analysis of large networks; (3) allow the determination of key network nodes and (4) help to predict network dynamics.

Conclusions/Significance: The concept opens a wide range of possibilities to develop new approaches and applications including network routing, classification, comparison and prediction.

Downloadable materials

ModuLand: Cytoscape plug-in containing the Linkland and ProportionalHill methods

ModuLand method: full package containing the NodeLand, LinkLand, Perturland, Edgeweight, ProportionalHill, GradientHill and Totalhill methods
Changes of version 1.3 (June 2012)

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Successful applications of the ModuLand method

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Published by the LINK-Group | Editor: Péter Csermely | Last updated on 10 09 2013
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