LINK-group

Tamás Korcsmáros

I am the principal investigator of the Network Biology Group at Eotvos Lorand University (http://netbiol.elte.hu). We work in close cooperation with the LINK-Group led by Prof. Peter Csermely and with Illés J. Farkas at the Statistical and Biological Physics Research Group of the Hungarian Academy of Sciences. Our completed research projects include (1) the development of a signalling pathway database, which focuses especially on signalling cross-talk, (2) the identification of novel signalling proteins, (3) the development of the PathwayLinker webservice that analyzes the signalling pathway memberships of proteins as well as their interactors for experiment design and evaluation.

Personal

  • Place and date of birth: Budapest, 8th, October, 1982
  • Nationality: Hungarian
  • Address: Palánta street 21. Budapest, Hungary, H-1025
  • Phone: +36-30-268-6590
  • E-mail: Korcsmáros@netbiol.elte.hu
  • Hobby: Running on long distances, film watching, home biology library building, traveling, care for my iguana and dog

Research areas

  • regulation of signaling networks
  • systems adaptation to stress
  • theoretical and applied network biology
  • systems biology of aging and cancer
  • network pharmacology

Education

  • 1997-2002: Secondary School of the Kürt Foundation
  • 2002-2007: Eötvös Loránd University of Science, Budapest, Faculty of Biology
  • 2005-2007: Specialization: Molecular Biology and Biochemistry

Research and Professional Experience

  • 2001-2005 Research Associate, Semmelweis Univ. Dept. Med. Chem.
  • 2001-2003: Chaperone group: Redox adaptation in diabetes and in alfa-1-antitrypsin deficient transgenic mice
  • 2005-2009 LinkGroup: Robustness and adaptation of the metazoan signaling networks
  • 2008- Researcher at Eötvös Loránd University (Dept. of Genetics and Dept. of Biological Physics)
  • 2009- Group leader, Network Biology Group, Eötvös Loránd University

Teaching Experience

  • 2010- Systems biology lectures for health care students (Semmelweis University)
  • 2010- Bioinformatics lecture and training course for MSc students (biology, biophysics)
  • 2011- Genetics training course (genome browsers) for BSc students (biology)

Honors and Awards

  • 2001 2nd National Competition for Research Students: Section of Biochemistry: 1st place
  • 2002 Hungarian Innovative and Scientific Competition: Commendatory place
  • 2003 National Competition for University Research Students in Biology:
    Junior award
  • 2004 Research Student Conference of the Semmelweis Medical University:
    3rd place
  • 2004 3rd National Competition for Research Students, Section of Biology:
    3rd place
  • 2005 Dean's Award of the Faculty of Science (ELTE) for outstanding
    organizational work for the Biologists' Research Student Movement
  • 2005 Honorary Member of the Hungarian Research Student Association
  • 2007 Research Student Conference of the Semmelweis Medical University:
    Commendatory place
  • 2009 FEBS Young SysBio Investigator Award
  • 2007 Research Student Conference of the Eötvös Loránd University, Section of Genetics: 1st place for Petra Rovó mentored by Tamás Korcsmáros
  • 2009 Research Student Conference of the Eötvös Loránd University, Section of Genetics: 2nd place for Dávid Fazekas mentored by Tamás Korcsmáros

Organizational Experiences:

  • 2001-2004: Vice president, president and managing president of the Hungarian Research Student Association
  • 2002-2008 Vice president of the Charity Commissioners of the Research Student Foundation
  • 2004-2007: Student President of the Biology Research Student Movement at the Eötvös Loránd University of Science
  • 2005-2007: Founding organizer of the Old Research Student Movement
  • 2003-2005: Secretary of the Organizing Committee of the 9th IUBMB Conference & 30th FEBS Congress held in Budapest, Hungary 2005
  • 2005-2007: Secretary of the Organizing Committee of the World Conference of Stress, Budapest, Hungary 2007
  • 2005- Vice president of the Hungarian Cell Stress Society
  • 2006- Director of the Predinet Ltd.
  • 2007-2010: Student secretary of the Research Student Council of the
    Faculty of Science, Eötvös University
  • 2008- President of the Charity Commissioners of the Research Student Foundation
  • 2008- Chairman of the Foundation for Old Research Students
  • 2009-2011 Secretary of the Organizing Committee of 30th National Competition for University Research Students in Biology

Publication

Publications on research topics:

  1. Nardai G., Korcsmáros, T. and Csermely, P. (2002) Reduction of the endoplasmic reticulum accompanies the oxidative damage of diabetes mellitus, In: Redox regulation (eds.: A. Pompella, G. Banhegyi and M. Wellman-Rousseau), NATO Science Series, I/347, 281-289.
  2. Nardai G., Korcsmáros, T., Papp, E. and Csermely, P. (2003) Reduction of the endoplasmic reticulum accompanies the oxidative damage of diabetes mellitus. Biofactors 17, 259-267.IF: 1,7
  3. Papp, E., Korcsmáros, T., Nardai G., and Csermely, P. (2004) Changes of cellular redox homeostasis and protein folding in diabetes, In: Cellular dysfunction in atherosclerosis and diabetes - Reports from bench to bedside (eds.: M. Simionescu, A. Sima, D. Popov), Plenum Press, 228-235.
  4. Nardai G., Stadler, K., Papp, E., Korcsmáros, T. Jakus, J., and Csermely, P. (2005) Diabetic changes in the redox status of the microsomal protein folding machinery. Biochemical and Biophysical Research Communications 334, 787-795. IF: 2,9
  5. Nardai, G., Papp, E., Korcsmáros, T., Stadler, K., Jakus, J. and Csermely, P. (2005) Possible links between metabolism and oxidative protein folding. Conseqences of a diabetes study, In: Redox regulation (eds.: A. Pompella, G. Banhegyi and M. Wellman-Rousseau), NATO Science Series, vol. 363, 101-109.
  6. Papp, E., Nardai, G., Sreedhar, A.S., Korcsmáros, T. and Csermely, P. (2005) Effects of unfolded protein accumulation on the redox state of the endoplasmic reticulum, In: Redox regulation (eds.: A. Pompella, G. Banhegyi and M. Wellman-Rousseau), NATO Science Series, vol. 111-119.
  7. Papp E., Szaraz P., Korcsmáros T. and Csermely, P. (2006) Changes of endoplasmic reticulum chaperone complexes, redox state, and impaired protein disulfide reductase activity in misfolding alfa-1-antitrypsin transgenic mice. FASEB Journal 20 (7): 1018-20. IF: 6.8
  8. Korcsmáros, T., Kovacs, I. A., Szalay, M. S. and Csermely, P (2006) Molecular chaperones: The modular evolution of cellular networks. Journal of Bioscience 32 (3): 441-446. IF: 1,5
  9. Szalay, M., Kovács, I.A., Korcsmáros, T., Böde. C. and Csermely, P. (2007) Stress-induced rearrangements of cellular networks: consequences for protection and drug design. FEBS Lett. 581(19):3675-80. IF: 3,5
  10. Böde, C., Kovacs, I.A., Szalay M., Palotai, R., Korcsmáros, T. and Csermely, P. (2007) Network analysis of protein dynamics. FEBS Lett. 581(15):2776-82. IF: 3,5
  11. Csermely, P., Korcsmáros, T. and Sulyok, K. (eds., 2007) Stress Responses in Biology and Medicine: Stress of Life in Molecules, Cells, Organisms, and Psychosocial Communities. Annals of the New York Academy of Sciences, vol. 1113, pp. 366.
  12. Korcsmáros, T., Szalay, M., Böde. C., Kovács, I.A., and Csermely, P. (2007) How to design multi-target drugs: Target-search options in cellular networks. Exp. Op. Drug Discovery 2 (6): 799-808.
  13. Csermely, P., Korcsmáros, T., Kovács, I.A., Szalay M.S. and Sõti, C. (2008) Systems biology of molecular chaperone networks. In: The biology of extracellular molecular chaperones. Novartis Foundation Symposium Series Vol. 291, Wiley, pp. 45-58.
  14. Korcsmáros T*, Farkas IJ*, Szalay MS, Rovó P, Fazekas D, Spiro Z, Böde C, Lenti K, Vellai T, Csermely P (2010) Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery. Bioinformatics 26:2042-2050
  15. Korcsmáros T*, Szalay MS*, Rovó P, Palotai R, Fazekas D, Lenti K, Farkas I J, Csermely P, Vellai T (2011) Signalogs: orthology-based identification of novel signaling pathway components in three metazoans. PLoS ONE 8, e19240
  16. I. J. Farkas, T. Korcsmáros, I. A. Kovács, Á. Mihalik, R. Palotai, G. I. Simkó, K. Z. Szalay, M. Szalay-Bekő, T. Vellai, S. Wang, P. Csermely. Network-based tools in the identification of novel drug-targets. Sci. Signal. 4, pt3 (2011).

Conference talks

  1. Tamás Korcsmáros, Illes J. Farkas, David Fazekas, Mate Szalay, Petra Rovo, Zoltan Spiro, Csaba Böde, Katalin Lenti, Tibor Vellai, and Peter Csermely: Complex networks in molecular biological regulation (in Hungarian). Annual Meeting of the Hungarian Biochemical Society, 23-26 August 2009, Budapest, Hungary
  2. Tamás Korcsmáros, Illés J. Farkas, Dávid Fazekas, Máté S. Szalay, Petra Rovó, Zoltán Spiró, Csaba Böde, Katalin Lenti, Tibor Vellai, Péter Csermely: Cellular signaling networks and their visualization. NetSci 2010 - The International School and Conference on Network Science, 10-14 May, 2010, Boston, USA
  3. Korcsmáros T. Fazekas D., Farkas I.J.: PathwayLinker: Linking proteins to signaling pathways for experiment design and evaluation. FEBS Young Scientist Forum 23-26 June 2010, Hindasgarden, Sweden
  4. Korcsmáros T. Fazekas D., Farkas I.J.: PathwayLinker: Linking proteins to signaling pathways for experiment design and evaluation. FEBS Congress 2010, 26 June – 1 July 2010, Gothenburg, Sweden

Conference posters

  1. Tamás Korcsmáros, Mate Szalay, Petra Rovo, Zoltan Spiro, Tibor Vellai, and Peter Csermely: SignaLink, a signaling pathway database: theoretical and practical applications (in Hungarian). Annual Meeting of the Hungarian Biochemical Society, 31 August - 3 September 2008, Szeged, Hungary
  2. Tamás Korcsmáros, Mate Szalay, David Fazekas, Petra Rovo, Zoltan Spiro, Tibor Vellai, and Peter Csermely: SignaLink, a signaling pathway database: theoretical and practical applications. FEBS SysBio Workshop, 7-13 March 2009, Alpbach, Austria
  3. T. Korcsmáros, I. J. Farkas, M. S. Szalay, P. Rovó, D. Fazekas, Z. Spiró, C. Böde, K. Lenti, T. Vellai, and P. Csermely: A signaling pathway resource for cross-talk analysis in C.elegans, Drosophila, and humans. ICSB 2009, 30 August – 4 September 2009, Stanford, USA
  4. T. Korcsmáros, I. J. Farkas, M. S. Szalay, P. Rovó, D. Fazekas, Z. Spiró, C. Böde, K. Lenti, T. Vellai, and P. Csermely: A signaling pathway resource for cross-talk analysis in C.elegans, Drosophila, and humans. FEBS Protein Modules Workshop, 5 - 10 September 2009, Seefeld in Tirol, Austria
  5. Korcsmáros T., Fazekas D., Farkas I.J.: PathwayLinker: Linking proteins to signaling pathways for experiment design and evaluation. FEBS Young Scientist Forum, 23-26 June 2010, Hindasgarden, Sweden
  6. Korcsmáros T., Fazekas D., Farkas I.J.: PathwayLinker: Linking proteins to signaling pathways for experiment design and evaluation. FEBS Congress 2010, 26 June - 1 July 2010, Gothenburg, Sweden
  7. Illés J. Farkas, Tamás Korcsmáros, Dávid Fazekas, Máté S. Szalay, Petra Rovó, Zoltán Spiró, Csaba Böde, Katalin Lenti, Tibor Vellai, Péter Csermely: Uniform curation of metazoan signaling pathways – resource and tool for experiment design and evaluation. Conference on multi-scale dynamics and evolvability of biological networks, 4-6 October, 2010, Leipzig, Germany
  8. Tamás Korcsmáros, Illés J. Farkas, Dávid Fazekas, Máté S. Szalay, Petra Rovó, Zoltán Spiró, Csaba Böde, Katalin Lenti, Tibor Vellai, Péter Csermely: Uniform curation of metazoan signaling pathways – resource and tool for experiment design and evaluation. ICSB 2010, 10-14 October 2010, Edinburgh, UK
  9. Tamás Korcsmáros, Eszter Ari, David Fazekas, Dezso Modos, Tibor Vellai and Peter Csermely: Comparison of signaling pathway proteins and the analysis of their evolutionary rate reveal the role of cross-talking proteins in three metazoans. EvoSysBio Workhop of ICSB 2010, 15 October 2010, Edinburgh, UK

Publications on talent recruitment

  1. Csermely, P., Borsodi, Z., Korcsmáros, T. és Pató, B. (2002) Six Years of Scientific Research Training in Hungary. Progress, Plans, Problems. In: Science Education: Talent Recruitment and Public Understanding, (Csermely, P. and Lederman, L. eds.) NATO Science Series, vol. V/38. pp. 191-198., IOS Press
  2. Csermely P., Amrein K., Borsodi Z., Korcsmar P., Korcsmáros T.,Pato B. and Tomor K. (2002) 5th National Conference of high school researchers (in Hungarian). Természet Világa 133, IX-XI
  3. Borsodi Z., Csermely P., Korcsmáros T. and Pato B. (2002) Research Opportunities for high school students (in Hungarian) Magyar Felsőoktatás, 12-13.
  4. Borsodi Z., Csermely P., Korcsmáros T. and Pato B. (2002) Research Opportunities for high school students (in Hungarian) Magyar Tudomány, 108, 673-676.
  5. Csermely P., Borsodi Z., Korcsmáros T. and Pato B. (2002) Gifted students in high school and in university, plenary presentation, Hungarian Teacher Conference
  6. Csermely, P., Korcsmáros, T. és Lederman, L. (eds., 2005) Science Education: Best Practices of Research Training for Students under 21, NATO Science Series, V/47. IOS Press, 235 pages.
  7. Sulyok K., Soter A., Minarik F., Szalay M., Fazekeas L., Korcsmáros T. (2005) Nationwide mentorship network for talented high school students in Hungary. In: Science Education: Best Practices of Research Training for Students under 21, NATO Science Series, V/47., pp. 186-190., IOS Press
  8. Böde, C. and Korcsmáros T. (2006) eKut, the Next Step for old high school research students. In: Csermely, P., Korlevic, K. and Sulyok, K. (eds.) Science Education: Models and Networking of Student Research Training under 21, NATO Security through Science Series, Human and Societal Dynamics E, V/16., pp. 55-58., IOS Press

Patents

  • Csermely, P., Korcsmaros, T., Kovacs, I. and Szalay, M. (2006) Method for analyzing the fine structure of networks. Patent application WO2007093960.

Memberships, Societies:

  • Hungarian Biological Society, Section of Animal Biology
  • Hungarian Biochemical Society, Section of Molecular Biology
  • Hungarian Cell Stress Society
  • Hungarian Research Student Association
  • Durrell Wildlife Conservation Trust
  • Dian Fossey Gorilla Fund

Tamás Korcsmáros
Published by the LINK-Group | Editor: Péter Csermely | Last updated on 10 09 2013
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