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Dr. Zsolt Bikádi

Personal

Education

  • József Attila University MSc in Chemistry, 1999
  • Eötvös University PhD in Bioorganic Chemistry, 2003

Research and Professional Experience:

  • 1999-2002 Chemical Research Center, Hungarian Academy of Sciences, Department of Molecular Pharmacology
    Modelling of intermolecular interactions
    Carotenoid supramolecules
  • 2002-2006 Postdoc at the Chemical Research Center of the Hungarian Academy of Sciences
    • Modelling of receptor activation
    • Modelling of ligand binding properties of serum proteins
    • Association of P450 enzymes and its effect on their catalytic activity
  • 2006-  Virtua Drug Ltd., CEO

Honours and Awards

  • Bolyai Fellowship 2004-2006
  • Young Researcher Award of the Chemical Research Center  2002

Scientific Commissions, Board and Society Memberships

  • QSAR and Modeling Workgroup of the Hungarian Chemical Society
  • Bioorganic Chemistry Workgroup of the Hungarian Academy of Sciences

Language Skills

  • English:  Advanced level
  • German:  Intermediate level

Publication list

  1. Hazai, E., Bikadi, Z., Zsila, F. and Lockwood, S. F. (2007) Non-covalent binding of disodium disuccinate astaxanthin to the catalytic site of phosphodiesterase 5A: A molecular modeling study. Letters In Drug Design & Discovery, 4, 128-136. IF: -, IC: -
  2. Bikadi, Z., Demko, L. and Hazai, E. (2007) Functional and structural characterization of a protein based on analysis of its hydrogen bonding network by hydrogen bonding plot. Arch Biochem Biophys. IF: 3.152, IC: -
  3. Hazai, E. and Bikadi, Z. (2007) Homology modeling of breast cancer resistance protein (ABCG2). J Struct Biol. 1047-8477
  4. Bikadi, Z., Ivanyi, R., Szente, L., Ilisz, I. and Hazai, E. (2007) Cyclodextrin complexes: chiral recognition and complexation behaviour. Curr Drug Discov Technol, 4, 282-294. 1570-1638
  5. Bikadi, Z., Hazai, E., Zsila, F. and Lockwood, S. F. (2006) Molecular modeling of non-covalent binding of homochiral (3S,3 ' S)-astaxanthin to matrix metalloproteinase-13 (MMP-13). Bioorganic & Medicinal Chemistry, 14, 5451-5458. IF: 2.286, IC: 1
  6. Zsila, F., Matsunaga, H., Bikadi, Z. and Haginaka, J. (2006) Multiple ligand-binding properties of the lipocalin member chicken alpha(1)-acid glycoprotein studied by circular dichroism and electronic absorption spectroscopy: The essential role of the conserved tryptophan residue. Biochimica Et Biophysica Acta-General Subjects, 1760, 1248-1273. IF: 2.418, IC: -
  7. Hazai, E., Visy, J., Fitos, I., Bikadi, Z. and Simonyi, M. (2006) Selective binding of coumarin enantiomers to human alpha(1)-acid glycoprotein genetic variants. Bioorganic & Medicinal Chemistry, 14, 1959-1965. IF: 2.286, IC: -
  8. Joshi, P. R., Suryanarayanan, A., Hazai, E., Schulte, M. K., Maksay, G. and Bikadi, Z. (2006) Interactions of Granisetron with an agonist-free 5-HT3A receptor model. Biochemistry, 45, 1099-1105. IF: 3.848, IC: -
  9. Hazai, E., Bikadi, Z., Zsila, F. and Lockwood, S. F. (2006) Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase. Bioorg Med Chem, 14, 6859-6867. IF: 2.286, IC: 1
  10. Lockwood, S. F., Penn, M. S., Hazen, S. L., Bikadi, Z. and Zsila, F. (2006) The effects of oral Cardax (disodium disuccinate astaxanthin) on multiple independent oxidative stress markers in a mouse peritoneal inflammation model: influence on 5-lipoxygenase in vitro and in vivo. Life Sci, 79, 162-174. IF: 2.512, IC: -
  11. Bikadi, Z., Kurdi, R., Balogh, S., Szeman, J. and Hazai, E. (2006) Aggregation of cyclodextrins as an important factor to determine their complexation behavior. Chem Biodivers, 3, 1266-1278. IF: 1.416, IC: -
  12. Schulte, M. K., Hill, R. A., Bikadi, Z., Maksay, G., Parihar, H. S., Joshi, P. and Suryanarayanan, A. (2006) The Structural Basis of Ligand Interactions in the 5-HT3R. (Ed, Arias, H.) Research Signpost, pp. 127-154.
  13. Lockwood, S. F., Penn, M. S., Hazen, S. L., Bikadi, Z. and Zsila, F. (2006) The effects of oral Cardax (TM) (disodium disuccinate astaxanthin) on multiple independent oxidative stress markers in a mouse peritoneal inflammation model: influence on 5-lipoxygenase in vitro and in vivo. Life Sciences, 79, 162-174.
  14. Bikadi, Z., Hazai, E., Simonyi, M. and Kupfer, D. (2005) Differential enantioselectivity in methoxychlor O-demethylation by CYP2C enzymes. Febs Journal, 272, 364-364. IF: 3.164 (Conference), IC: -
  15. Hazai, E., Bikadi, Z., Simonyi, M. and Kupfer, D. (2005) Association of cytochrome P450 enzymes is a determining factor in their catalytic activity. Febs Journal, 272, 374-374. IF: 3.164 (Conference), IC: -
  16. Zsila, F. and Bikadi, Z. (2005) trans-Parinaric acid as a versatile spectroscopic label to study ligand binding properties of bovine beta-lactoglobulin. Spectrochimica Acta Part A-Molecular And Biomolecular Spectroscopy, 62, 666-672. IF: 1.290, IC: 1
  17. Foss, B. J., Sliwka, H. R., Partali, V., Kopsel, C., Mayer, B., Martin, H. D., Zsila, F., Bikadi, Z. and Simonyi, M. (2005) Optically active oligomer units in aggregates of a highly unsaturated, optically inactive carotenoid phospholipid. Chemistry-A European Journal, 11, 4103-4108. IF: 4.907, IC: -
  18. Joshi, P. R., Suryanarayanan, A., Bikadi, Z., Mani, M. and Schulte, M. K. (2005) Investigation of amino acids in the loop B region of the mouse 5-HT3AR by site directed mutagenesis. Faseb Journal, 19, A519-A519. IF: 7.064 (Conference), IC: -
  19. Zsila, F., Bikadi, Z. and Lockwood, S. F. (2005) In vitro binding of leukotriene B4 (LTB4) to human serum albumin: evidence from spectroscopic, molecular modeling, and competitive displacement studies. Bioorg Med Chem Lett, 15, 3725-3731. IF: 2.478, IC: -
  20. Suryanarayanan, A., Joshi, P. R., Bikadi, Z., Mani, M., Kulkarni, T. R., Gaines, C. and Schulte, M. K. (2005) The loop C region of the murine 5-HT3A receptor contributes to the differential actions of 5-hydroxytryptamine and m-chlorophenylbiguanide. Biochemistry, 44, 9140-9149. IF: 3.848, IC: 2
  21. Zsila, F., Bikadi, Z. and Lockwood, S. F. (2005) In vitro binding of leukotriene B-4 (LTB4) to human serum albumin: Evidence from spectroscopic, molecular modeling, and competitive displacement studies. Bioorganic & Medicinal Chemistry Letters, 15, 3725-3731.
  22. Zsila, F., Fitos, I., Bikadi, Z., Simonyi, M., Jackson, H. L. and Lockwood, S. F. (2004) In vitro plasma protein binding and aqueous aggregation behavior of astaxanthin dilysinate tetrahydrochloride. Bioorganic & Medicinal Chemistry Letters, 14, 5357-5366. IF: 2.333, IC: 1
  23. Zsila, F., Bikadi, Z. and Simonyi, M. (2004) Circular dichroism spectroscopic studies reveal pH dependent binding of curcumin in the minor groove of natural and synthetic nucleic acids. Organic & Biomolecular Chemistry, 2, 2902-2910. IF: 2.194, IC: 2
  24. Zsila, F., Bikadi, Z. and Simonyi, M. (2004) Induced circular dichroism spectra reveal binding of the antiinflammatory curcumin to human alpha(1)-acid glycoprotein. Bioorganic & Medicinal Chemistry, 12, 3239-3245. IF: 2.018, IC: 3
  25. Fitos, I., Visy, J., Zsila, F., Bikadi, Z., Mady, G. and Simonyi, M. (2004) Specific ligand binding on genetic variants of human alpha(1)-acid glycoprotein studied by circular dichroism spectroscopy. Biochemical Pharmacology, 67, 679-688. IF: 3.436, IC: 3
  26. Zsila, F., Bikadi, Z., Fitos, I. and Simonyi, M. (2004) Probing protein binding sites by circular dichroism spectroscopy. Curr Drug Discov Technol, 1, 133-153. IF: -, IC: -
  27. Maksay, G., Simonyi, M. and Bikadi, Z. (2004) Subunit rotation models activation of serotonin 5-HT3AB receptors by agonists. J Comput Aided Mol Des, 18, 651-664. IF: 2.729, IC: -
  28. Maksay, G., Simonyi, M. and Bikadi, Z. (2004) Subunit rotation models activation of serotonin 5-HT3AB receptoirs by agonists. Journal of Computer-Aided Molecular Design, 18, 651-664.
  29. Maksay, G., Bikadi, Z. and Simonyi, M. (2003) Binding interactions of antagonists with 5-hydroxytryptamine(3A) receptor models. Journal Of Receptors And Signal Transduction, 23, 255-270. IF: 2.000, IC: 18
  30. Bikadi, Z. and Simonyi, M. (2003) Muscarinic and nicotinic cholinergic agonists: Structural analogies and discrepancies. Current Medicinal Chemistry, 10, 2611-2620. IF: 4.904, IC: 4
  31. Simonyi, M., Bikadi, Z., Zsila, F. and Deli, J. (2003) Supramolecular exciton chirality of carotenoid aggregates. Chirality, 15, 680-698. IF: 1.793, IC: 14
  32. Zsila, F., Bikadi, Z. and Simonyi, M. (2003) Molecular basis of the Cotton effects induced by the binding of curcumin to human serum albumin. Tetrahedron-Asymmetry, 14, 2433-2444. IF: 2.178, IC: 8
  33. Zsila, F., Bikadi, Z. and Simonyi, M. (2003) Unique, pH-dependent biphasic band shape of the visible circular dichroism of curcumin-serum albumin complex. Biochemical And Biophysical Research Communications, 301, 776-782. IF: 2.836, IC: 6
  34. Zsila, F., Bikadi, Z. and Simonyi, M. (2003) Probing the binding of the flavonoid, quercetin to human serum albumin by circular dichroism, electronic absorption spectroscopy and molecular modelling methods. Biochemical Pharmacology, 65, 447-456. IF: 2.993, IC: 34
  35. Zsila, F., Bikadi, Z. and Simonyi, M. (2002) Retinoic acid binding properties of the lipocalin member beta-lactoglobulin studied by circular dichroism, electronic absorption spectroscopy and molecular modeling methods. Biochemical Pharmacology, 64, 1651-1660. IF: 3.542, IC: 9
  36. Bikadi, Z., Zsila, F., Deli, J., Mady, G. and Simonyi, M. (2002) The supramolecular structure of self-assembly formed by capsanthin derivatives. Enantiomer, 7, 67-76. IF: 1.189, IC: 13
  37. Zsila, F., Imre, T., Szabo, P. T., Bikadi, Z. and Simonyi, M. (2002) Induced chirality upon binding of cis-parinaric acid to bovine beta-lactoglobulin: spectroscopic characterization of the complex. Febs Letters, 520, 81-87. IF: 3.912, IC: 3
  38. Zsila, F., Bikadi, Z. and Simonyi, M. (2002) Further insight into the molecular basis of carotenoid-albumin interactions: circular dichroism and electronic absorption study on different crocetin-albumin complexes. Tetrahedron-Asymmetry, 13, 273-283. IF: 2.163, IC: 3
  39. Zsila, F., Bikadi, Z. and Simonyi, M. (2001) Induced chirality upon crocetin binding to human serum albumin: origin and nature. Tetrahedron-Asymmetry, 12, 3125-3137. IF: 2.265, IC: 3
  40. Zsila, F., Deli, J., Bikadi, Z. and Simonyi, M. (2001) Supramolecular assemblies of carotenoids. Chirality, 13, 739-744. IF: 1.554, IC: 4
  41. Zsila, F., Bikadi, Z., Keresztes, Z., Deli, J. and Simonyi, M. (2001) Investigation of the self-organization of lutein and lutein diacetate by electronic absorption, circular dichroism spectroscopy, and atomic force microscopy. Journal Of Physical Chemistry B, 105, 9413-9421. IF: 3.379, IC: 9
  42. Tong, D., Hetenyi, C., Bikadi, Z., Gao, J. P. and Hjerten, S. (2001) Some studies of the chromatographic properties of gels ('artificial antibodies/receptors') for selective adsorption of proteins. Chromatographia, 54, 7-14. IF: 1.741, IC: 18
  43. Zsila, F., Bikadi, Z., Deli, J. and Simonyi, M. (2001) Chiral detection of carotenoid assemblies. Chirality, 13, 446-453. IF: 1.554, IC: 7
  44. Bikadi, Z., Keresztury, G., Holly, S., Egyed, O., Mayer, I. and Simonyi, M. (2001) Role of secondary interactions in the conformational equilibrium of 2,6-diisopropylphenol. Journal Of Physical Chemistry A, 105, 3471-3474. IF: 2.898, IC: 1
  45. Zsila, F., Bikadi, Z., Deli, J. and Simonyi, M. (2001) Configuration of a single centre determines chirality of supramolecular carotenoid self-assembly. Tetrahedron Letters, 42, 2561-2563. IF: 2.280, IC: 2

     


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