Personal

• E-mail: Eszter.Hazai [at] virtuadrug.com

Education

• 2004-2006 Postdoc at the Chemical Research Center of the Hungarian Academy of Sciences
• 2002-2004: Postdoc position at University of Massachusetts Medical Center Department of Biochemistry and Molecular Pharmacology
• 2003: Ph.D in Structural Biochemistry 1999: MA Chemist-English translator 1996: University of Hamburg, chemist, Hamburg, Germany
• 1993-1999: Eötvös Loránd University, Faculty of Science, Chemist –English translator

Research and Professional Experience:

• 2006- CEO, Virtua Drug
• 2004-2006: Postdoc at the Chemical Research Center of the Hungarian Academy of Sciences Association of P450 enzymes and its effect on their catalytic activity
• 2002-2004: Postdoc position at University of Massachusetts Medical Center Department of Biochemistry and Molecular Pharmacology Glucuronidation of the oxidative metabolites of methoxychlor by human hepatic UDP-glucuronosyl transferases Interactions between P450 enzymes and its influence on methoxychlor metabolism
• 1999-2002: Chemical Research Center, Hungarian Academy of Sciences, Department of Biochemical Pharmacology Inhibition of the formation of NAPQI, the toxic metabolite of acetaminophen Cytochrome P450 enzymes
• 1996.07.-09.: Beiersdorf Abteilung Zentralanalytik, Hamburg, Germany

Honours and Awards

• 2005 Kisfaludy Lajos Award 2005 (Kisfaludy Lajos Foundation)
• 2002 FEBS Congress fellowship: Advanced course on cytochrome P450s

Scientific Commissions, Board and Society Memberships

• Society of Hungarian Toxicologists
• Hungarian Biochemical Society
• Bioorganic Chemistry Workgroup of the Hungarian Academy of Sciences

Language Skills

• English: MA English Translator
• German: Advanced level

Publication list

1. Hazai, E., Bikadi, Z., Zsila, F. and Lockwood, S. F. (2007) Non-covalent binding of disodium disuccinate astaxanthin to the catalytic site of phosphodiesterase 5A: A molecular modeling study. Letters In Drug Design & Discovery, 4, 128-136. IF: -, IC: -
2. Bikadi, Z., Demko, L. and Hazai, E. (2007) Functional and structural characterization of a protein based on analysis of its hydrogen bonding network by hydrogen bonding plot. Arch Biochem Biophys. IF: 3.152, IC: 1
3. Hazai, E. and Bikadi, Z. (2007) Homology modeling of breast cancer resistance protein (ABCG2). J Struct Biol. IF: 3.496, IC: -
4. Bikadi, Z., Ivanyi, R., Szente, L., Ilisz, I. and Hazai, E. (2007) Cyclodextrin complexes: chiral recognition and complexation behaviour. Curr Drug Discov Technol, 4, 282-294. IF: 1.616, IC: -
5. Bikadi, Z., Hazai, E., Zsila, F. and Lockwood, S. F. (2006) Molecular modeling of non-covalent binding of homochiral (3S,3 ' S)-astaxanthin to matrix metalloproteinase-13 (MMP-13). Bioorganic & Medicinal Chemistry, 14, 5451-5458. IF: 2.286, IC: 1
6. Hazai, E., Visy, J., Fitos, I., Bikadi, Z. and Simonyi, M. (2006) Selective binding of coumarin enantiomers to human alpha(1)-acid glycoprotein genetic variants. Bioorganic & Medicinal Chemistry, 14, 1959-1965. IF: 2.286, IC: 2
7. Joshi, P. R., Suryanarayanan, A., Hazai, E., Schulte, M. K., Maksay, G. and Bikadi, Z. (2006) Interactions of Granisetron with an agonist-free 5-HT3A receptor model. Biochemistry, 45, 1099-1105. IF: 3.848, IC: -
8. Hazai, E., Bikadi, Z., Zsila, F. and Lockwood, S. F. (2006) Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase. Bioorg Med Chem, 14, 6859-6867. IF: 2.286, IC: 2
9. Bikadi, Z., Kurdi, R., Balogh, S., Szeman, J. and Hazai, E. (2006) Aggregation of cyclodextrins as an important factor to determine their complexation behavior. Chemistry & Biodiversity, 3. IF: 1.416, IC: -
10. Bikadi, Z., Hazai, E., Simonyi, M. and Kupfer, D. (2005) Differential enantioselectivity in methoxychlor O-demethylation by CYP2C enzymes. Febs Journal, 272, 364-364. IF: 3.164 (Conference), IC: -
11. Hazai, E., Bikadi, Z., Simonyi, M. and Kupfer, D. (2005) Association of cytochrome P450 enzymes is a determining factor in their catalytic activity. Febs Journal, 272, 374-374. IF: 3.164 (Conference), IC: -
12. Zsila, F., Hazai, E. and Sawyer, L. (2005) Binding of the pepper alkaloid piperine to bovine beta-lactoglobulin: Circular dichroism spectroscopy and molecular modeling study. Journal Of Agricultural And Food Chemistry, 53, 10179-10185. IF: 2.507, IC: 4
13. Monostory, K., Kohalmy, K., Hazai, E., Vereczkey, L. and Kobori, L. (2005) Role of CYP2E1 in deramciclane metabolism. Drug Metabolism And Disposition, 33, 1717-1722. IF: 4.015, IC: -
14. Hazai, E. and Kupfer, D. (2005) Interactions between CYP2C9 and CYP2C19 in reconstituted binary systems influence their catalytic activity: Possible rationale for the inability of CYP2C19 to catalyze methoxychlor demethylation in human liver microsomes. Drug Metabolism And Disposition, 33, 157-164. IF: 4.015, IC: 9
15. Hazai, E., Bikadi, Z., Simonyi, M. and Kupfer, D. (2005) Association of cytochrome P450 enzymes is a determining factor in their catalytic activity. J Comput Aided Mol Des, 19, 271-285. IF: 2.082, IC: 5
16. Hazai, E., Gagne, P. V. and Kupfer, D. (2004) Glucuronidation of the oxidative cytochrome P450-mediated phenolic metabolites of the endocrine disruptor pesticide: Methoxychlor by human hepatic UDP-glucuronosyl transferases. Drug Metabolism And Disposition, 32, 742-751. IF: 4.015, IC: -
17. Monostory, K., Hazai, E. and Vereczkey, L. (2004) Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. Chemico-Biological Interactions, 147, 331-340. IF: 1.558, IC: 9
18. Hazai, E. and Kupfer, D. (2003) Glucuronidation of the oxidative P450 mediated metabolites of the endocrine disruptor pesticide-methoxychlor. Drug Metabolism Reviews, 35, 54-54. IF: 4.537 (Conference), IC: -
19. Tamasi, V., Hazai, E., Porsmyr-Palmertz, M., Ingelman-Sundberg, M., Vereczkey, L. and Monostory, K. (2003) GYKI-47261, a new AMPA [2-amino-3-(3-hydroxymethylisoxazole-4-yl)propionic acid] antagonist, is a CYP2E1 inducer. Drug Metabolism And Disposition, 31, 1310-1314. IF: 4.015, IC: 1
20. Hazai, E., Simon-Trompler, E., Czira, G., Vereczkey, L. and Monostory, K. (2002) New LC method using radioactivity detection for analysis of toxic metabolite of acetaminophen (paracetamol). Chromatographia, 56, S75-S78. IF: 1.317, IC: -
21. Hazai, E., Vereczkey, L. and Monostory, K. (2002) Reduction of toxic metabolite formation of acetaminophen. Biochemical And Biophysical Research Communications, 291, 1089-1094. IF: 2.946, IC: 17
22. Hazai, E., Monostory, K., Bakos, A., Zacher, G. and Vereczkey, L. (2001) [About paracetamol again]. Orv Hetil, 142, 345-349. IF: -, IC: -
23. Hazai, E., Rona, K. and Vereczkey, L. (1999) [Human drug metabolizing enzymes III. Epoxide hydrolases, esterases, and amidases]. Acta Pharm Hung, 69, 208-212. IF: -, IC: